Author

D. J. Thornton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

R. K. Grencis· 3 shared A. De Sciscio· 1 shared A. Gillis· 1 shared A. J. Bancroft· 1 shared A. J. Macpherson· 1 shared A. J. Reid· 1 shared A. O. Speak· 1 shared A. Parrish· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

R. K. Grencis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The UIP honeycomb airway cells are the site of mucin biogenesis with deranged cilia

J. A. Herrera, L. A. Dingle, M. A. Montero, V. Rajamiyer, J. Blaikley, F. Granato, S. Pearson, C. Lawless, D. J. Thornton

The paper uses spatial proteomics to compare fibrotic and non-fibrotic airway cells in UIP, finding deregulated pathways and identifying key proteins associated with mucin biogenesis and ciliogenesis.

bioRxiv · Sep 3, 2022Pathology

Mucin-degrading gut bacteria promote anti-parasitic immunity

M. Wolter, M. Boudaud, E. Grant, A. Parrish, A. De Sciscio, S. Thompson, J.-J. Gerardy, M. Mittelbronn, D. J. Thornton, A. J. Macpherson, R. K. Grencis, M. S. Desai

This study shows that mucin-degrading gut bacteria influence anti-parasitic immunity by modulating host immune responses, with dietary fiber affecting this interaction.

bioRxiv · Feb 28, 2022 · PreprintImmunology

Defining the early stages of intestinal colonisation by whipworms

M. A. Duque Correa, D. Goulding, F. Rodgers, C. Cormie, K. A. Rawlinson, A. Gillis, A. J. Bancroft, H. M. Bennett, M. Lotkowska, A. J. Reid, A. O. Speak, P. Scott, N. Redshaw, C. McCarthy, C. Brandt, , M. Berriman

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

bioRxiv · Aug 21, 2020Immunology

Trickle infection and immunity to Trichuris muris

M. Glover, S. A. P. Colombo, D. J. Thornton, R. K. Grencis

This study shows that repeated low-dose infection with Trichuris muris leads to gradual immunity, with CD4+ T cells playing a key role, and alters gut microbiota.

PLOS Pathogens · Nov 15, 2019Peer-reviewedImmunology

Disulfide disruption reverses mucus dysfunction in allergic airway disease

L. E. Morgan, S. K. Shenoy, D. Raclawska, N. A. Emezienna, V. L. Richardson, N. Hara, A. Q. Harder, H. M. El-Batal, C. M. Magin, D. E. G. Villalon, G. Duncan, J. S. Hanes, J. S. Suk, D. J. Thornton, F. Holguin, , C. M. Evans

This study shows that reducing disulfide bonds in mucins reverses mucus dysfunction in asthma by improving mucociliary clearance and reducing airway hyperreactivity.

bioRxiv · Sep 14, 2019Physiology