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This study shows that intestinal microbiota enhances the anti-tumor effect of oncolytic virus vaccine in advanced colorectal cancer by modulating T-cell activity.

The paper tests if corticosterone mediates sex reversal in frogs and finds no significant dose-effect relationship, but notes urban habitats increase sex reversal and reduce fitness.

This study shows that the R14del mutation in phospholamban increases pentamer stability, reducing its ability to regulate SERCA and impairing cardiac calcium handling during physiological stress.

The paper shows that viral channelrhodopsins (VCR1s) induce intracellular calcium release upon illumination, enabling light-controlled muscle contraction in tadpoles, suggesting a new optogenetic tool.

The paper examines how hypoxia affects P-gp and BCRP transporter expression and activity in fetal brain endothelial cells, showing differing responses in early and mid-gestation.

The study shows that short-term fasting followed by refeeding significantly alters gut and liver physiology in rainbow trout, regardless of diet composition, while diet changes have minimal impact during refeeding.

This study examines how orchiectomy and intermittent hypoxia interact to affect hepatic oxidative stress and gene expression in mice.

The paper shows that macrophage-specific lipid nanoparticle therapy blocks lung mechanosensitive immunity by inhibiting Ca2+ responses and TNF secretion in alveolar macrophages.

This study identifies HNF4α regulation of QPRT expression in the kidney as a mechanism enhancing resilience against acute kidney injury.

This study shows that crickets can fragment ingested microplastics into smaller pieces during digestion, potentially acting as agents of plastic transformation in the environment.

This study examines how phosphorylation of RyR2 affects dyad size and tetramer arrangement in response to isoproterenol using mutant mice.

This study investigates how adiponectin deficiency affects atherosclerosis differently in males and females, revealing sex- and age-dependent changes in plaque content, inflammation, and vascular smooth muscle cell behavior.

This study shows resistance exercise increases mitophagy and mitophagosomes in human skeletal muscle, with BNIP3L as a marker of mitophagy flux.

This study investigates factors affecting recovery from anhydrobiosis in tardigrades, finding age and episode duration significantly impact recovery success.

This paper shows that ALY688-SR reduces diaphragm fibrosis and atrophy in DMD mice by lowering mitochondrial stress, but not in tibialis anterior.

This paper identifies mechanistic biomarkers for epileptogenicity using computational modeling and SEEG data, showing that combining biomarkers improves seizure zone localization and reveals extended pathological networks beyond the clinically identified seizure zone.

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

This study tracks histopathological, biochemical, transcriptomic, and microbiome changes in mice fed a NASH-promoting diet over 30 weeks, revealing progressive NAFLD development and immune/xenobiotic gene expression changes.

This study examines how fluctuating temperatures affect the cost of development in common wall lizards, finding that higher temperature variance increases energy expenditure and reduces residual yolk reserves.