Discover, rate, and discuss biology preprints.

This study investigates how increased tendon compliance affects muscle spindle firing during different stretch types and finds that firing rates are generally reduced but not fully explained by fascicle length and velocity.

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

SanPy is a Python-based open-source pipeline for analyzing whole-cell current-clamp recordings, providing tools for parameter extraction, visualization, and quality control.

This study shows linaclotide stimulates bicarbonate secretion in CFTR-deficient tissues by enhancing DRA expression, suggesting DRA as a therapeutic target for CF-related intestinal dysfunction.

This study investigates TGF-β ligand interactions in C. elegans immune response, showing cooperative roles among ligands and distinct signaling pathway involvement.

This study shows that tetrahydrocurcumin reduces adipose angiogenesis and related metabolic parameters in obese mice by downregulating VEGF, MMP-2, and MMP-9.

This study develops a high-resolution fecal pharmacokinetic model in mice to analyze antibiotic concentrations and inter-individual variability.

This study examines the hypoxia response of Polar cod under different temperatures, finding low Pcrit but no metabolic downregulation or anaerobic response, suggesting metabolic compensation rather than tolerance.

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

This study identifies STIM1's role in coordinating diastolic depolarization in mouse sinoatrial node cells by interacting with HCN4 channels.

This study shows that the D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice by disrupting nuclear-cytosolic Ca2+ coupling.

This study shows exercise reduces flow recirculation and activates SCD1 to produce anti-inflammatory metabolites in endothelial cells.

This study shows ghrelin improves cellular and organismal features of HGPS by promoting autophagy and clearing progerin, extending lifespan in a mouse model.

This study shows that reducing Arf6 in endothelial cells impairs insulin-stimulated vasodilation and causes systemic insulin resistance.

This paper develops an electromagnetic circuit to precisely control body temperature in mice over long periods, showing it can induce both normothermia and hyperthermia without toxic effects.

This study identifies nitric oxide as the only neurotransmitter that inhibits cilia beating in ctenophores, suggesting a unique signaling mechanism for cilia control.

This study investigates how rapid cold hardening (RCH) affects anoxia-induced spreading depolarization in locusts by examining ion regulation mechanisms.

The paper discovers a lymphatic bridge connecting Schlemm's canal to limbal and conjunctival lymphatic pathways using advanced imaging techniques in mice.

This study shows that deleting Mtfp1 in hepatocytes increases mitochondrial respiration and protects against fatty liver disease.