Author

J. Y. Lu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. Ablaeva· 3 shared Z. Zhang· 3 shared A. Seluanov· 2 shared D. Firsanov· 2 shared E. Hillpot· 2 shared F. T. Zakusilo· 2 shared S. A. Biashad· 2 shared V. Gorbunova· 2 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

J. Ablaeva

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

Y. Zhao, Z. Zheng, Z. Zhang, E. Hillpot, Y. S. Lin, F. T. Zakusilo, J. Y. Lu, J. Ablaeva, R. A. Miller, E. Nevo, A. Seluanov, V. Gorbunova

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

bioRxiv · May 8, 2023Evolutionary Biology

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

D. Firsanov, M. Zacher, X. Tian, Y. Zhao, T. L. Sformo, G. Tombline, S. A. Biashad, A. Gilman, N. Hamilton, A. Patel, M. Straight, M. Lee, J. Y. Lu, E. Haseljic, A. Williams, , Gladyshev

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

bioRxiv · May 7, 2023 · PreprintCancer Biology

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

Z. Zhang, X. Tian, J. Y. Lu, K. Boit, J. Ablaeva, F. T. Zakusilo, S. Emmrich, D. Firsanov, E. Rydkina, S. A. Biashad, Q. Lu, A. Tyshkovskiy, V. N. Gladyshev, S. Horvath, A. Seluanov, V. Gorbunova

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

bioRxiv · May 4, 2023 · PreprintPhysiology