Discover, rate, and discuss biology preprints.

The paper develops and presents a computational model of electrolyte and water transport along nephrons in a mammalian kidney under various conditions.

This study investigates the role of activin/inhibin β subunits in zebrafish development and reproduction, showing their critical role in folliculogenesis and ovarian homeostasis.

This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.

This study shows that loss of hepatic PEPCK1 impairs acute exercise glucose regulation but improves liver lipid reduction and muscle mitochondrial adaptations with exercise training in mice.

This study investigates whether cold stress increases gut permeability in locusts by testing bacterial and fluorescent dextran leakage, finding no significant increase.

This study shows that loss of CFTR function reduces T2R-stimulated NO production in nasal epithelial cells and macrophages, impairing immune responses to gram-negative bacteria.

The paper examines genetic variability in sorghum transpiration and water use efficiency under varying evaporative demand, finding a positive correlation between transpiration and WUE in high evaporative demand conditions.

This study examines how physical activity and sedentary time jointly affect VO2max in adolescents using compositional analysis, finding that PA intensity has a greater impact than reducing sedentary time.

The paper shows that phase-dependent stability measures in a compass walker model do not predict gait robustness or fall risk.

This study examines the trade-off between basal thermal tolerance and heat hardening plasticity in larval amphibians under different acclimation conditions.

This study uses in vivo imaging to assess cortical hemodynamic responses to tubuloglomerular feedback, showing that loop diuretics abolish these responses and phlorizin reduces microcirculatory flow.

This study examines the relationship between body condition score and triglyceride levels with other metabolic markers in overweight dogs, finding significant associations with cholesterol, insulin, and glucose.

The paper identifies β-arrestin binding sites in Drosophila neuropeptide GPCRs by analyzing their C-terminal tails and comparing sequence conservation across species.

This study tests the efficacy of GHRH agonist MR-356 in a murine model of cardiometabolic HFpEF, showing improvements in cardiac function and metabolic inflammation markers.

This study models how hip flexion and retraction affect energy cost in walking at different speeds, finding that asymmetric hip actuation reduces metabolic cost of transport by up to 6% at medium speeds.

This study shows that mental fatigue reduces muscle endurance and motivation but does not affect neural drive to muscles.

This study shows dehydration alters midgut gene expression in Aedes aegypti, enabling faster rehydration after bloodfeeding and potentially affecting pathogen transmission.

This study investigates the role of placental BPGM in fetal growth restriction using mouse models and human placental analysis, finding altered BPGM expression and 2,3 BPG levels in hypoxic conditions.

This study shows that Meis2 gene inactivation in mouse peripheral sensory neurons impairs cardiac baroreflex regulation, linking ASD-related sensory neuron dysfunction to cardiovascular autonomic imbalance.