Discover, rate, and discuss biology preprints.

This study uses tensor decomposition to analyze muscle activity and force patterns during grasping, revealing age-related changes in motor strategies and muscle couplings.

This study finds that sprinters have greater lower-limb relative mass but similar normalized moment of inertia compared to non-sprinters, suggesting mechanical difficulty in limb swinging is not increased.

This study examines how different anesthetics affect lung and systemic inflammation in mice exposed to ozone, finding that isoflurane reduces inflammation when given shortly before exposure, while ketamine/xylazine/atipamezole increases it.

This study finds that a long-term ketogenic diet increases SOX2-dependent oligodendrocyte and myelination gene expression in aged mouse brains.

This study identifies distinct gene expression patterns in human alpha cells from type 1 and type 2 diabetes, revealing disease-specific pathways of dysfunction.

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.

This study compares extracellular vesicles from skeletal muscle cells before and after differentiation, finding differences in size, protein yield, and marker expression, but no effect of acute contractile activity.

This study investigates how caloric restriction affects adipose tissue and metabolic health, finding that its benefits are sex- and age-dependent in mice and humans.

The paper identifies 707 O-GlcNAcylated proteins in cardiac tissue during pressure overload hypertrophy, finding 233 significantly increased, with validation of CPT1B and PDH.

This study shows that hypothalamic astrocytes regulate systemic glucose metabolism and energy balance through extra-synaptic glutamate signaling, offering new targets for obesity treatment.

This study shows that GSK3 inhibition improves skeletal muscle function and insulin sensitivity in mdx mice, either alone or combined with exercise.

This study compares stable isotope values from blubber and skin tissues of southern hemisphere humpback whales to assess their interchangeability for dietary analysis.

This study shows that deleting Sorbs2 in cardiomyocytes causes dilated cardiomyopathy in mice, with defects in microtubule polymerization and structural proteins, and links Sorbs2 variants to human cardiac diseases.

This study identifies a predictive link between systemic metabolism and cytokine signatures in the brain of APOE4 mice, showing APOE genotype-dependent differences in aging mice.

This study investigates the non-dipping blood pressure phenotype in Hsd11b2 knockout rats, linking it to autonomic nervous system dysfunction and dietary salt intake.

This study shows that Gi/o-GPCR inhibition of beta-cell insulin secretion depends on Na+/K+ ATPase activation, which hyperpolarizes the membrane and modulates Ca2+ oscillations.

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

This study shows that force accuracy training reduces motor unit firing rate variability in the vastus lateralis, improving force tracking accuracy without increasing muscle strength.