Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PhysiologybioRxiv
PIP2 regulation of TRPC5 channel activation and desensitization
M. Ningoo, L. D. Plant, A. Greka, D. E. Logothetis
This study investigates how PIP2 regulates TRPC5 channel activation and desensitization through gating control rather than cell surface density.
DOI 10.1016/j.jbc.2021.100726 - PhysiologybioRxiv
Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots
The paper develops a microstructure-aware model for biochemical transport in arterial blood clots, demonstrating coherent flow structures and permeation processes.
DOI 10.1016/j.jbiomech.2021.110692 - PhysiologybioRxiv
Succinate Dehydrogenase (SDH)-subunit C regulates muscle oxygen consumption and fatigability in an animal model of pulmonary emphysema.
J. Balnis, L. Drake, C. Vincent…·A. Jaitovich
The paper investigates the role of SDH subunit C in muscle oxygen consumption and fatigability in an animal model of pulmonary emphysema, finding that SDHC regulates respiration and fiber type composition.
DOI 10.1165/rcmb.2020-0551oc - PhysiologybioRxivPreprint
Inspiratory muscle training for enhancing repeated-sprint ability: A pilot study
R. F. Rodriguez, R. J. Aughey, F. Billaut, N. E. Townsend
This pilot study investigates the effect of inspiratory muscle training on repeated-sprint ability and reoxygenation, finding no significant group differences but suggesting the need for larger samples to detect effects.
- PhysiologybioRxiv
Genetically Engineered Strains for Combinatorial Cardiovascular Optobiology
F. K. Lee, J. C. Lee, B. Shui…·M. I. Kotlikoff
The paper introduces 21 genetically engineered mouse lines for combinatorial optogenetic studies in cardiovascular biology, enabling biallelic combination of effectors and sensors in multiple cell types.
DOI 10.7554/elife.67858 - PhysiologybioRxiv
LAM - an image analysis method for regionally defined organ-wide cellular phenotyping of the Drosophila midgut
A. Viitanen, J. Gullmets, J. Morikka…·V. Hietakangas
The paper introduces LAM, an imaging method to analyze regional cellular phenotypes in Drosophila midgut, revealing regional heterogeneity in ISC responses to colitis.
DOI 10.1016/j.crmeth.2021.100059 - PhysiologybioRxiv
An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins
A. M. Blawas, K. E. Ware, E. Schmaltz…·J. A. Somarelli
This study identifies ALOX5 upregulation during breath-holding in dolphins as a potential molecular mechanism for ischemic tolerance during diving.
DOI 10.1093/emph/eoab036 - PhysiologybioRxivPreprint
A Simple Ultrafast Multicolor Immunolabelling and Clearing Approach for Whole-Organ and Large Tissue 3D Imaging
L. Biswas, J. Chen, J. De Angelis…·A. Kusumbe
The paper introduces SUMIC, a fast and simple method for whole-organ and large tissue 3D imaging, revealing age-related expansion of lymphatic vessels in endocrine tissues.
- PhysiologybioRxiv
Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model
R. L. Bell, G. S. Withers, F. A. Kuypers…·A. Bhargava
This study shows that stress and CRF increase NEC risk in formula-fed neonatal rats, while CRF antagonism reduces NEC incidence and severity.
DOI 10.1371/journal.pone.0246412 - PhysiologybioRxiv
Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury
G. A. Gusarova, S. Das, M. N. Islam…·J. Bhattacharya
The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.
DOI 10.1172/jci.insight.135753 - PhysiologybioRxiv
Adipocyte deletion of the RNA binding protein HuR induces cardiac hypertrophy and fibrosis
A. R. Guarnieri, S. R. Anthony, A. Gozdiff…·M. Tranter
This study shows that deleting HuR in adipose tissue causes cardiac hypertrophy and fibrosis, likely through inflammation and vesicle transport changes in subcutaneous white adipose tissue.
DOI 10.1152/ajpheart.00957.2020 - PhysiologybioRxiv
Biceps femoris long head sarcomere and fascicle length adaptations after three weeks of eccentric exercise training
P. A. Pincheira, M. A. Boswell, M. V. Franchi…·G. A. Lichtwark
This study investigates if three weeks of eccentric exercise increases Biceps femoris long head fascicle length through sarcomere addition, finding instead that sarcomere length increases without changes in sarcomere number.
- PhysiologybioRxiv
Selection for feed efficiency elicits different postprandial plasma metabolite profiles in response to poor hygiene of housing conditions in growing pigs
A. Zem Fraga, I. Louveau, P. H. R. F. Campos…·N. Le Floch
This study compares postprandial plasma metabolite profiles in pigs selected for feed efficiency under good or poor housing hygiene conditions, finding differences in insulin, triglycerides, and amino acid levels between low- and high-RFI lines.
DOI 10.1371/journal.pone.0246216 - PhysiologybioRxiv
Does non-invasive vagus nerve stimulation affect heart rate variability? A living and interactive Bayesian meta-analysis
V. Wolf, A. Kuehnel, V. Teckentrup…·N. B. Kroemer
This paper performs a living Bayesian meta-analysis of 17 studies on taVNS effects on HRV, finding no significant effect and questioning HRV as a robust biomarker for acute taVNS.
DOI 10.1111/psyp.13933 - PhysiologybioRxivPreprint
The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS
M. N. Islam, G. A. Gusarova, S. R. Das…·J. Bhattacharya
The paper shows that mitochondrial Ca2+ uniporter (MCU) expression in alveolar type 2 cells determines ARDS severity by affecting Ca2+ buffering capacity.
- PhysiologybioRxiv
RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth
C. Noviello, K. Kobon, L. Delivry…·A. Sotiropoulos
This study shows RhoA in myofibers promotes hypertrophy by regulating satellite cell fusion through ECM remodeling and macrophage recruitment without affecting protein synthesis.
DOI 10.1016/j.isci.2021.103616 - PhysiologybioRxivPreprint
Heterozygous mutation of Vegfr3 decreases renal lymphatics but is dispensable for renal function
H. Liu, C. Hiremath, Q. Patterson…·D. K. Marciano
This study shows that heterozygous Vegfr3 mutation reduces renal lymphatics but does not impair renal function or histology, even after cisplatin injury.
- PhysiologybioRxiv
Enhanced CICR activity reduces ER Ca2+ level in cells expressing CPVT-linked mutant RyR2
N. Kurebayashi, T. Murayama, R. Ohta…·T. Sakurai
This paper quantitatively examines how CPVT-linked RyR2 mutations affect ER Ca2+ release threshold by measuring CICR activity and simulating cellular responses.
DOI 10.1085/jgp.202112869