Author

V. Hietakangas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:Drosophila· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Viitanen· 2 shared J. Mattila· 2 shared A. Gupta· 1 shared A. Jaiswal· 1 shared A. Krisko· 1 shared A. Lippi· 1 shared A. Meinander· 1 shared A. Nieminen· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersPhysiology

A. Viitanen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Stem cell growth directs region-specific cell fate decisions during intestinal nutrient adaptation

J. Mattila, A. Viitanen, G. Fabris, J. Korzelius, V. Hietakangas

This study shows that nutrient signaling through mTORC1 regulates intestinal stem cell size and directs region-specific cell fate decisions, with implications for tissue integrity during aging.

bioRxiv · Apr 24, 2023 · PreprintPhysiology

Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity

J. Paukstyte, R. M. Lopez Cabezas, Y. Feng, K. Tong, D. Schnyder, E. Elomaa, P. Gregorova, M. Doudin, M. Sarkka, J. Sarameri, A. Lippi, H. Vihinen, J. Juutila, A. Nieminen, P. Toronen, , J. Saarikangas

The paper identifies age-related protein structural changes in yeast and shows that inhibiting polymerization of glutamate synthase extends lifespan.

bioRxiv · Jan 23, 2023Cell Biology

LAM - an image analysis method for regionally defined organ-wide cellular phenotyping of the Drosophila midgut

A. Viitanen, J. Gullmets, J. Morikka, P. Katajisto, J. Mattila, V. Hietakangas

The paper introduces LAM, an imaging method to analyze regional cellular phenotypes in Drosophila midgut, revealing regional heterogeneity in ISC responses to colitis.

bioRxiv · Jan 20, 2021Physiology

Control of MYC-dependent apoptotic threshold by a co-amplified ubiquitin E3 ligase UBR5

X. Qiao, Y. Liu, M. L. Prada, A. Gupta, A. Jaiswal, M. Sharma, H. M. Haikala, K. Talvinen, L. Yetukuri, J. W. Pylvänäinen, J. Klefström, P. Kronqvist, A. Meinander, T. Aittokallio, V. Hietakangas, , J. Westermarck

This study identifies UBR5 as a novel MYC ubiquitin ligase that regulates MYC protein stability and apoptotic threshold in cancer cells and breast tissue.

bioRxiv · Jan 8, 2019 · PreprintCancer Biology

Nuclear actin is required for transcription during Drosophila oogenesis

M. Sokolova, H. M. Moore, B. Prajapati, J. Dopie, L. Merilainen, M. Honkanen, R. Cerejeira Matos, M. Poukkula, V. Hietakangas, M. Vartiainen

This study shows actin interacts with transcribed genes and Pol II in Drosophila, and its nuclear shuttling is essential for egg shell gene expression.

bioRxiv · Jun 28, 2018Cell Biology