Author

A. Greka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2

Frequent Co-Authors

C. Kim· 3 shared A. Subramanian· 2 shared A. Weins· 2 shared E.-H. Sidhom· 2 shared J. L. Marshall· 2 shared J. L. Pablo· 2 shared J. L. Shaw· 2 shared J. Marshall· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCell Biology

C. Kim

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

N. Wieder, J. M. Coraor Fried, C. Kim, E.-H. Sidhom, M. R. Brown, J. L. Marshall, C. Arevalo, M. Dvela-Levitt, M. Kost-Alimova, J. Sieber, K. R. Gabriel, J. Pacheco, C. B. Clish, H. S. Abbasi, S. Singh, , A. Greka

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

bioRxiv · Feb 19, 2023Cell Biology

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

G. Eraslan, E. Drokhlyansky, S. Anand, A. Subramanian, E. Fiskin, M. Slyper, J. Wang, N. Van Wittenberghe, J. M. Rouhana, J. Waldman, O. Ashenberg, D. Dionne, T. S. Win, M. S. Cuoco, O. Kuksenko, , A. Regev

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

bioRxiv · Jul 19, 2021Cell Biology

PIP2 regulation of TRPC5 channel activation and desensitization

M. Ningoo, L. D. Plant, A. Greka, D. E. Logothetis

This study investigates how PIP2 regulates TRPC5 channel activation and desensitization through gating control rather than cell surface density.

bioRxiv · Jan 25, 2021Physiology

Blocking the Rac1-TRPC5 pathway protects human podocytes

Y. Zhou, C. Kim, J. L. B. Pablo, F. Zhang, J. Y. Jung, L. Xiao, S. Bazua, M. Emani, C. Hopkins, A. Weins, A. Greka

This study shows TRPC5 inhibition protects human podocytes from injury in vitro and in vivo, supporting its therapeutic potential for kidney diseases.

bioRxiv · Aug 28, 2020 · PreprintCell Biology

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injury

A. R. Clark, J. Marshall, Y. Zhou, M. S. Montesinos, H. Chen, L. Nguyen, F. Chen, A. Greka

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.

bioRxiv · Jul 30, 2020Cell Biology

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

M. Malimova, E.-H. Sidhom, A. Satyam, M. Dvela-Levitt, M. Melanson, B. T. Chamberlain, S. L. Alper, J. Santos, J. Gutierrez, A. Subramanian, E. Grinkevich, E. R. Bricio, C. Kim, A. Clark, A. Watts, , A. Greka

The paper identifies Fostamatinib as a potential repurposing drug for acute lung injury by reducing MUC1 protein levels in preclinical models.

bioRxiv · Jun 30, 2020Cell Biology