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This study shows that DNA demethylases limit multigenerational methylation and transcriptome divergence by showing that their loss leads to increased methylation gains and transcriptome divergence in Arabidopsis.

This paper develops nanobody AAVX fusion proteins for AAV purification, quantification, and detection across multiple methods.

This paper develops tissue-derived insoluble type I and type II collagen inks for 3D printing of scaffolds, showing viable cell responses and dimensional stability.

This study estimates eye torsion during walking using head-mounted technology and shows its role in altering retinal flow for self-motion parameter extraction.

This study identifies Nuc1, a mitochondrial enzyme, as a regulator of an RNA surveillance system in yeast that limits replication of the L-A mycovirus.

The paper demonstrates that a well-designed prompting system outperforms model upgrades in generating scientific hypotheses, introducing a framework to create falsifiable, cross-domain hypotheses.

This study identifies and quantifies risky play-like behaviour in juvenile and young adult rats using ethological frameworks to assess developmental changes in engagement with elevated and unstable environments.

The paper identifies a highly active RecET recombinase pair for efficient homologous recombination in Streptomyces, enabling large DNA integration with minimal homology arms.

The paper develops T-SWITCH, a synthetic genetic switch that tracks T-DNA delivery and integration in plants, enabling integration-free genome editing.

The paper develops injectable nanoparticles that form soft, functionally segmented brain electrodes capable of neuronal stimulation and gene transfer in chicken embryos.

This study examines how physical exercise affects osteocyte lacunar morphology and orientation around bioresorbable implants in rats, showing increased lacunar size and altered orientation with exercise.

This study evaluates electrically enhanced intraperitoneal drug delivery using nanoparticles and fluorescence lifetime imaging microscopy to track drug penetration and intracellular release.

This paper presents a nearly complete haplotype-resolved chicken genome using trio-sequencing and long-read data, identifying gaps and structural variants in dot chromosomes.

This study creates a TIE2-L914F mouse model to study venous malformation progression and shows it responds to rapamycin treatment.

This study identifies PDGFD-ROCK-NMIIA signaling in pericytes as a driver of pathological neoangiogenesis in retinopathies, revealing cell-type-specific actomyosin contractility mechanisms.

This study evaluates a multi-target small-molecule cocktail, GUSTC, to reduce repressive heterochromatin marks in bovine fibroblasts, enhancing reprogramming potential without improving embryo development.

The paper presents a droplet-based workflow for antimicrobial screening in complex matrices, showing it can detect MICs at lower concentrations and reveal extract-specific aggregation effects.

The paper compares brain and kidney extracellular vesicle morphology and proteomics after inflammatory challenge, identifying significant protein changes but noting limitations in causal conclusions.

The paper shows that the Hha/TomB type VII TA system in E. coli promotes phage infection by activating cryptic prophage lytic genes, contrary to the typical phage inhibition role of TAs.

This study uses experimental evolution in seed beetles to show that structural variants and sex-specific genetic factors influence lifespan evolution.