Discover, rate, and discuss biology preprints.

This study shows Aedes aegypti mosquitoes use surface texture and integrate it with water salinity to select egg-laying sites, and texture affects their search behavior.

The paper shows that current source density estimation can produce incorrect results in dense electrode arrays due to small inter-electrode spacing.

This study uses patient-derived iPSCs to model a MIC13 variant causing mitochondrial liver disease, revealing metabolic defects and early fibrosis through multi-omics analysis.

This paper introduces a framework for identifying disease-associated features tailored to individual profiles using localized test statistics, applied to single-cell RNA sequencing data for Alzheimer's disease.

The paper introduces a collision-aware estimator for RNA-seq quantification that allows shorter UMIs without sacrificing accuracy.

This study shows that m6A methylation stabilizes genes involved in temozolomide resistance in glioblastoma, and inhibiting METTL3 can restore drug sensitivity.

This study shows that F. tularensis modulates the macrophage redox environment to suppress Aim2 inflammasome activation, revealing a mechanism by which it evades host immune responses.

This study identifies novel therapeutic targets for ulcerative colitis by analyzing transcriptomic data from multiple cohorts, distinguishing between inflammation-dependent and constitutive changes.

The paper investigates antiviral activity in alpine lake bacteria, develops synthetic communities with broad-spectrum antiviral properties, and links bacteriophage resistance to viral inactivation.

DAIseg is a new HMM-based method that detects both Neanderthal and Denisovan introgression in modern human genomes without archaic references, outperforming existing methods in Papuan populations.

The paper identifies susceptibility genes for septoria nodorum blotch in U.S. hard winter wheat using genetic markers and association studies.

This study identifies a novel R98Q mutation in PPO2 conferring resistance to sulfentrazone in common ragweed populations from Michigan.

This paper demonstrates a method to rehydrate proteins after soft-landing for cryo-EM by flash melting, enabling native configurations and improving sample preparation.

This paper modifies Nab-paclitaxel with receptor binders to improve tumor targeting and reduce toxicity, showing enhanced efficacy in cancer cells and xenograft models.

The paper identifies cell-autonomous and systemic circadian gene expression programs in adipocytes using RNA sequencing and motif analysis, revealing distinct regulatory programs linked to metabolic processes.

The paper shows that CRISPR-mediated herd immunity in E. coli promotes frequent homologous recombination by maintaining genetic diversity and enabling gene flow, enhancing adaptation rates.

This study shows ketamine reduces habenula activity during aversive learning in humans, supporting preclinical findings on its antidepressant mechanisms.

This study develops a DIA-based workflow for comprehensive ubiquitinome profiling in targeted protein degradation, identifying over 40,000 ubiquitylated peptides.

The paper introduces a framework to summarize RNA structural ensembles by identifying shared motifs and clustering structures, showing it can find conserved scaffolds and motifs across species and transcripts.

The paper links spontaneous eye-blink rate in young children to neural development of executive function through prefrontal cortex activation.