Discover, rate, and discuss biology preprints.

This study uses yeast large-scale absolute quantitative proteomics to reveal universal principles of protein resource allocation among cellular organelles and its relationship to physiological parameters and species divergence.

The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.

KmerSignificance Score (KSS) prioritizes viral k-mers by integrating strain-distinguishing capacity, mutation impact, and functional importance, achieving superior classification performance and cross-dataset comparability.

This study compares proteomic profiles of strong and weak biofilm-forming Acinetobacter baumannii isolates to identify potential therapeutic targets.

This study evaluates how selective sweeps affect DFE inference using fitdadi, finding that performance declines at low recombination rates and with unfolded SFS, but remains largely unbiased with a flexible demographic model.

The paper shows that some mitochondria-lacking planctomycetal bacteria can engulf prey, challenging mitochondria-first eukaryogenesis models.

This study identifies computational markers of rhythmic timing deficits in Parkinson's disease using the Adaptation and Anticipation Model applied to finger-tapping data.

This study develops aptamer-targeted PLGA nanoparticles for localized antibiotic delivery in prosthetic joint infections, showing improved biofilm targeting and prolonged drug retention.

This paper quantifies the fitness cost of parasite aggregation in entomopathogenic nematodes by linking dispersal behavior to population growth using experimental and modeling approaches.

The paper links habitual sleep duration to brain network controllability, finding longer workday sleep is associated with higher somatomotor controllability and lower visual cortex controllability.

The paper identifies three GCN2 activators, one of which works independently of GCN1, and describes its unique binding mechanism.

This study examines cryptic diversity in subarctic moss populations, revealing habitat-specific genetic differences and clonal structure that affect biodiversity estimates.

This paper introduces EVER, a post-processing strategy that enhances hydrogel bioconstruct resolution through shrinkage induced by excluded volume effects, achieving significant dimensional reduction while maintaining cell viability.

GROND improves electron crystallography by correcting multiple scattering, enhancing refinement accuracy and revealing hidden structural details in various materials.

clrcycle is a dimensionality reduction method for cyclic data that captures phase and magnitude in biological systems, showing effectiveness in circadian and cell-cycle analysis.

The paper investigates how neurotransmitter receptor organization in the human anterior temporal lobe relates to neurochemistry and semantic memory, finding coupled molecular-neurochemical relationships.

This study identifies the functional interplay between PBP1A and LdtJ in Acinetobacter baumannii, showing that disrupting their coordination weakens the cell envelope and increases colistin resistance.

CROP-1 predicts gene activity based on DNA sequence and regulatory state, enabling context-specific edit design in plants with higher accuracy than sequence-only models.

The paper measures electrostatic potentials of histone H3 tails using NMR and simulations to show how arginine-lysine balance affects their conformational behavior in nucleosome core particles.

This study uses acoustic telemetry to analyze movement patterns and habitat use of invasive blue crabs in a Mediterranean lagoon, revealing sex-specific behaviors and informing management strategies.