Discover, rate, and discuss biology papers.

This paper identifies key residues in Mycobacterium tuberculosis Ku and LigD that mediate their interaction, revealing a dual regulatory mechanism for LigD activity.

This study shows that selenium-enriched rapeseed extract enhances cisplatin's anti-cancer effects on colorectal cancer cells without harming normal cells.

This paper introduces DropHiChew and loop velocity to study DNA movement dynamics, enabling accurate trajectory estimation with shallow sequencing.

This study identifies self-cleaving ribozymes in RNA viruses, showing their role in translation initiation across fungi and plants.

This study identifies Leptospira species in dogs and rodents in Thailand, revealing new pathogen diversity and environmental associations.

This study uses HS-AFM to show yeast TOM complexes predominantly form trimers that dynamically dissociate into dimers and monomers, revealing structural and dynamic features of the TOM complex.

This study shows TCDD induces Cyp1a1 in murine skin, enhancing sebaceous gland differentiation and lipid production before causing Ahr-dependent seboatrophy.

The paper compares Vibrio genomes associated with coral white syndrome to identify virulence modules and horizontal gene transfer patterns.

This study identifies an IL-21R hypomorph mutation that specifically impairs STAT1 activation, revealing a nonredundant role for IL-21 in Tfh cell differentiation.

The yEvo Mutation Browser helps students and researchers visualize and interpret genome sequencing data from experimental evolution studies of yeast.

This review evaluates single-cell sequencing findings in pediatric acute leukemia, highlighting insights into clonal evolution, chemoresistance, and immune dynamics, while noting limitations in study design and bias.

This study identifies factors by which Mycobacterium tuberculosis suppresses Th17 responses during infection, showing that ESX-1 and PDIM inhibit IL-23 production in dendritic cells.

This study investigates the role of copy number variants (CNVs) disrupting Human Accelerated Regions (HARs) in neurodevelopmental disorders (NDDs) using a large cohort of 821 children, identifying three recurrent HAR loci associated with NDDs.

This study maps the topographic organization of the human zona incerta using diffusion MRI and connectivity analysis, revealing gradients and clusters linked to specific cortical regions and functions.

This study compares the effects of Nav1.7 and Nav1.8 inhibitors on human dorsal root ganglion neuron excitability, finding Nav1.7 inhibition has larger effects on action potential threshold and upstroke velocity but less impact on repetitive firing.

This study identifies an NF-κB-driven anti-apoptotic network in PC3 prostate cancer cells that contributes to resistance against oncolytic VSV, suggesting combination therapies may enhance virotherapy efficacy.

This study compares how human brains and large language models represent sentence meaning, finding that transformers poorly match brain representations despite capturing some structural aspects.

This paper provides a detailed ultrastructural analysis of pharyngeal sensory organs in Drosophila larvae, identifying and classifying different types of sensilla and neurons.

The paper quantifies Lewy pathology burden in the putamen across Lewy body diseases and finds it accumulates in excitatory synapses before synaptic degeneration.

This study examines evolutionary rate shifts in carnivorous plants to understand convergent and lineage-specific genomic adaptations.