Andreas S. Thum

Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

This paper provides a detailed ultrastructural analysis of pharyngeal sensory organs in Drosophila larvae, identifying and classifying different types of sensilla and neurons.

Context makes the difference: Temporally Resolved Dopaminergic Teaching Signals Shape Associative Memory in Drosophila Larvae

The paper shows how specific dopaminergic neurons in Drosophila larvae modulate memory formation through temporally precise signaling during learning.

The 3D micro- and nanostructure of the apical extracellular matrix in Drosophila

This study maps the 3D structure of the Drosophila larval apical extracellular matrix using electron microscopy, revealing intricate ultrastructural features and their functional roles.

Octopamine receptors at a glance: from expression and anatomical maps to their role in development and behavior in the Drosophila melanogaster larva

The paper compiles and analyzes a complete set of octopamine receptor mutant lines in Drosophila melanogaster to study their expression, function, and role in development and behavior.

Selective octopaminergic tuning of mushroom body circuits during memory formation

This study re-examines the role of octopamine in learning and memory in Drosophila larvae, showing it modulates dopaminergic neurons to orchestrate memory processes.

A switch in arousal circuit architecture shapes sleep across the lifespan

The paper identifies distinct octopaminergic neuron populations in Drosophila that drive arousal in larvae and adults, revealing a developmental switch in sleep-wake circuit architecture.

Finding a path: Local search behavior of Drosophila larvae

This paper describes the local search behavior of Drosophila larvae in response to food stimuli and investigates the role of internal versus external cues in their navigation.

Morphology and ultrastructure of external sense organsof Drosophila larvae

This paper describes the morphology and ultrastructure of external sense organs in Drosophila larvae using 3D electron microscopy, identifying three main types of sensilla and their spatial organization.

Drosophila Bchs overexpression recapitulates human WDFY3 neurodevelopmental phenotypes with implications for glial cell involvement in altered head circumference

This study shows that overexpression of the Drosophila Bchs gene, an ortholog of human WDFY3, causes neural developmental issues in both neurons and glial cells, mirroring human neurodevelopmental disorders.

Rewarding capacity of optogenetically activating a giant GABAergic central-brain interneuron in larval Drosophila

The paper investigates the role of the APL neuron in larval Drosophila, finding that optogenetic activation can induce a rewarding effect through dopaminergic pathways.

Developmental emergence of sleep rhythms enables long-term memory capabilities in Drosophila

This study identifies when circadian sleep emerges in Drosophila larvae and shows its role in enabling long-term memory.

Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis

The paper identifies Warming Cells and Cooling Cells in Drosophila that use cross-inhibition to regulate thermal homeostasis through coordinated behavioral responses.

Reward signaling in a recurrent circuit of dopaminergic neurons and Kenyon cells

The paper demonstrates a recurrent signaling loop between dopaminergic neurons and Kenyon cells in Drosophila larvae that mediates reward information and enhances memory persistence.

Multilevel feedback architecture for adaptive regulation of learning in the insect brain

The paper maps the synaptic connectome of the Drosophila larva mushroom body and identifies feedback pathways that enable modulatory neurons to compute teaching signals for reinforcement learning.

The Complete Connectome Of A Learning And Memory Center In An Insect Brain

The paper reconstructs the complete synaptic connectome of the Drosophila larval mushroom body, revealing novel circuit structures and input integration patterns in Kenyon cells.