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This study shows how food ration interacts with temperature to alter proteomic responses to heat stress in mussels, affecting mRNA processing, translation, and cytoskeletal stability.

This study identifies the distinct roles of Rab5 and Rab11 in regulating neural circuit assembly through endosome-mediated trafficking.

The paper shows that vocal tract variation among individuals leads to consistent phonetic differences, suggesting a neutral-like evolutionary process in language sound development.

The paper uses molecular dynamics simulations and experimental assays to show MBD2 binds methylated CpG DNA with a bistable equilibrium, involving two stable conformations with different affinities.

This paper demonstrates that Z-modified TFOs can repress endogenous gene expression by forming stable triplexes at GC-rich regulatory elements.

The paper identifies extensive interactions among C2H2 zinc finger proteins at chromatin loop anchors using ChIP-seq, interactome data, and chromatin interaction maps.

The paper identifies SMiTE, a commensal-derived bacteriocin that effectively inhibits multiple Streptococcus pneumoniae serotypes without harming commensals.

The paper shows that cobamide concentrations predict microbial dominance in co-cultures, suggesting niche differentiation despite functional redundancy.

The paper establishes a multi-omic PDX resource linking GBM invasion phenotypes to molecular programs and therapeutic responses, identifying two invasion modes and a neurodevelopmental factor associated with tumor growth and survival.

The paper determines the structure of Llp and analyzes the FhuA:Llp complex to understand superinfection exclusion in bacteriophage T5.

The paper characterizes the synaptic connectome of neurosecretory cells in Drosophila, revealing their regulatory roles in physiology and behavior through input and output pathways.

The paper presents a standardized experimental protocol and analysis framework for fluorescence-based CRISPR enzyme assays to improve reproducibility and consistency in kinetic measurements.

This study shows that host-secreted lactate from viral-infected airway epithelial cells reduces macrophage antibacterial activity by reprogramming their metabolism.

The paper investigates environmental and geographic factors influencing plant diversity in South American coastal lomas, finding an inverse latitudinal gradient shaped by climate, topography, and human impact.

On 489 evaluable new Mac1 complexes, AlphaFold3, Chai-1 and Boltz-2 placed over half of ligands within 2 Å, but on docking hit-lists AF3 and Boltz-2 added little over docking.

This paper introduces LigHTS, a method to create biomimetic hydrogels in standard microplates for high-throughput screening, enabling tunable thickness and topography with improved reproducibility.

AlphaFold3 pLDDT matches AlphaFold2 at calling disordered residues (Matthews correlation 0.693 vs 0.701); on disorder-containing complexes mean DockQ is similar, but interface features explain less variance (42% vs 58%).

The paper investigates low frequency depression (LFD) in synapses and finds it results from synaptic vesicle undocking rather than depletion of the readily releasable pool.

This paper estimates the full-frequency whole-head profile of age effects on resting-state MEG and shows the effect is replicable and robust across datasets and covariates.