Mahdi Bagherpoor Helabad

The paper uses molecular dynamics simulations and experimental assays to show MBD2 binds methylated CpG DNA with a bistable equilibrium, involving two stable conformations with different affinities.

This paper introduces MLEE, a machine learning-assisted enzyme engineering workflow that improves hit rates for high-fitness enzyme variants compared to traditional methods.

The paper shows that biased ligands of the AT1R receptor stabilize different conformations that differentially modulate β-arrestin interactions, affecting signaling and desensitization.

The paper determines the atomic structure of mutant huntingtin exon 1 fibrils using integrative analysis and molecular dynamics simulations combined with experimental data.