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Habitat degradation destabilizes complex metacommunities by disrupting dispersal

This study shows habitat degradation shifts metacommunities from stable to unstable regimes, increasing extinction risk, and highlights dispersal's role in stabilizing ecosystems.

Particle-Associated Prokaryotic Community Structures in the Bering and Chukchi Seas

The paper examines particle-associated prokaryotic communities in the Bering and Chukchi Seas, finding that lifestyle and water-mass origin, not depth, structure these communities.

Explainable Multimodal Prognostic Modeling Uncovers New Clinically Relevant Pathological Features in a Multi-Institutional Pancreatic Neuroendocrine Tumor Cohort

This paper develops a multimodal prognostic model for pancreatic neuroendocrine tumors using clinicopathologic data and histology images, finding that stromal features are as prognostic as tumor cells.

Glioblastoma model mouse rescue from mortality by brain-targeted catalytically-enhanced angiotensin-converting enzyme 2 mutant-antibody fusion protein

The paper shows that combining ACE2dm-s1 with a STING agonist improves survival in GBM model mice, unlike losartan alone, and suggests ACE2dm-s1 modulates the tumor microenvironment.

Ecology of gene drives: Organism fitness under larval competition determines gene drive performance

This study investigates how larval competition affects gene drive performance in Aedes aegypti mosquitoes using agent-based models and Bayesian optimization.

MULTI-COHORT TRANSCRIPTOMIC ANALYSIS REVEALS SHARED INFLAMMATORY SIGNALING AND UROTHELIAL DYSFUNCTION ACROSS IC/BPS PHENOTYPES

This study identifies shared molecular signatures of inflammation and urothelial dysfunction across different IC/BPS phenotypes using multi-cohort transcriptomic analysis.

Discontinuation of GLP-1RA Treatment Reinstates Binge-Like Eating and Drives Body Weight Past Pre-Treatment Levels in Mice

This study shows that stopping GLP-1RA treatment in mice with binge-like eating restores binge behavior and leads to weight gain beyond pre-treatment levels.

Deep phenomics of human PBMCs using a 31-marker spectral flow cytometry panel

The paper develops a 31-marker spectral flow cytometry panel to simultaneously profile functional cytokines, AIMs, and FoxP3+ Tregs in human PBMCs under different conditions.

PLATE: a global atlas of food metaplasmidomes

PLATE provides a global resource of food metaplasmidomes, offering curated catalogs and annotations for studying plasmid diversity and function in food ecosystems.

Plant-plant communication in tomato: mechanisms underpinning information transfer between plants

This study investigates plant-plant communication in tomato by analyzing metabolomic and volatile emissions changes in response to herbivory, showing mirror effects in immune system reprogramming between sender and receiver plants.

Comparative molecular analysis of histopathologic subtypes reveals shared epithelial remodeling yet distinct fibroblast programs in scleroderma lung disease

This study compares molecular features of SSc-NSIP and SSc-UIP with IPF, finding shared epithelial changes and distinct fibroblast programs.

Autonomous generalizability auditing of scientific foundation models

This paper introduces AutoSPECTRA, a protocol for auditing generalizability of scientific foundation models across biological domains.

Role of Very Long-Chain Fatty Acyl-Ceramides in Endocytic Uptake

This study identifies VLC fatty acyl-ceramides as essential for endocytic invagination by interacting with endocytic machinery and ORPs.

A red fluorescent sensor for intensity-and lifetime imaging of cAMP in living cells

The paper develops a red fluorescent sensor, chILI, for detecting cAMP in living cells through intensity and lifetime imaging, demonstrating its use in mouse brain neurons.

RBM25 selectively stabilizes XBP1s mRNA independently of splicing factor activity

This study identifies RBM25 as a post-transcriptional regulator that selectively stabilizes XBP1s mRNA during ER stress, enhancing UPR signaling and cellular survival.

Steering Before Selection: Energy-Limited Developmental Control as a Phenotypic Capacitor, a Pre-Specified Simulation Study

This paper uses simulations to show that developmental control conceals genetic variation from selection, acting as an energy-dependent phenotypic capacitor that can be beneficial if harmful mutations are reversed.

Platelet-endothelial crosstalk drives distinct endothelial dysfunction in bicuspid aortic valve disease

This study shows that platelet-derived signals cause distinct endothelial dysfunction in bicuspid aortic valve disease, leading to mitochondrial dysfunction and immune cell recruitment.

XAMPGen: An Interpretable SI Pipeline For Novel Antimicrobial Peptide Discovery

This paper introduces XAMPGen, an interpretable generative model for discovering novel antimicrobial peptides using fine-tuned protein language models and explainable AI techniques.

2D U-NET Deep Learning Architecture for Atherosclerotic Lesion Segmentation and Quantification

This paper develops a 2D U-NET model to segment and quantify atherosclerotic lesions in mouse aortic sections, achieving high accuracy and significantly reducing measurement time.

Linking dynamic photosynthetic traits to biomass: a functional data framework that pinpoints when photosynthesis limits growth

The paper models genotype-specific photosynthetic trait trajectories using functional data analysis to predict biomass, finding that early growth period traits most strongly influence final dry weight.