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Locomotor activity enhances environmental representation by boosting visuo-frontal communication

The paper shows that locomotion enhances visuo-frontal communication, improving visual processing and behavioral performance in macaques.

CARTnet: Template-guided B-cell Epitope Prediction with Contact-aware Attention

CARTnet improves B-cell epitope prediction using a contact-aware deep learning framework, outperforming existing methods on internal and external datasets.

Multi-faceted role of dopamine afferents to the ventral pallidum in reward processing

This study investigates the role of dopamine afferents to the ventral pallidum in reward processing using circuit tracing, fibre photometry, and behavioural pharmacology in male rats.

Cascaded Dual-Targeting (WTW/TAT) Liposomes Delivery DOX for Precision Glioblastoma Treatment

This paper develops a dual-targeting liposomal nanoplatform for glioblastoma treatment, showing improved drug delivery across the BBB and enhanced tumor suppression.

Virus coinfection in plants determined by ecological responses to environmental heterogeneity

This study investigates virus coinfection in plants by analyzing environmental and ecological factors across multiple host species and communities, finding that most coinfections are random interactions driven by environmental responses.

Long read sequencing reveals changes in measured isoform structure and abundance due to RNA processing

The paper compares RNA sequencing protocols using long-read sequencing, finding significant changes in isoform structure and abundance due to RNA processing steps.

Squalene as a Candidate Signalling Molecule: Computational Evidence for a Predicted KEAP1 Interaction and Implications for Stress-Induced Altruistic Stem-Cell Niche Protection

This paper investigates the structural feasibility of squalene interacting with the KEAP1 Kelch domain using molecular docking and provides a hypothesis for its role in NRF2 regulation under stress.

Antibiotic-induced protein mislocalization drives hypervesiculation in Salmonella

This study shows antibiotic-induced envelope stress in Salmonella disrupts compartmentalization, enabling PBP5 and ACP interaction that drives hypervesiculation.

Generalizable virtual staining from histopathology to spatial proteomics across biological scales

This study introduces QUEST, a model that uses H&E histology to predict spatial protein expression, enabling virtual staining and analysis across biological scales.

ALIGN: A modular framework for quantitative analysis of longitudinal development in Caenorhabditis elegans

ALIGN provides a modular framework for analyzing longitudinal development in C. elegans, enabling accurate segmentation, quality control, and motion correction across imaging conditions.

Phenotypic plasticity segregates antagonistic species but undermines their coexistence

The paper shows that environmental-induced phenotypic plasticity can promote coexistence in antagonistic bacterial species by spatial segregation, but removing this segregation leads to higher coexistence through adaptive plasticity.

Distinct patterns of multisensory integration underly the expression of flavor preferences and aversions in rats

This study shows that rats integrate taste and smell signals differently depending on the valence of flavor components, challenging the MLE framework for multisensory integration.

The Pregnane X Receptor (PXR) contributes to phenotypic plasticity and modulates the sensitivity to targeted therapies in melanoma

This study shows that PXR expression in melanoma cells increases sensitivity to BRAFi/MEKi treatment and is linked to a melanocytic phenotype.

HiFiTaxa: a reproducible analysis pipeline for full length 16S rRNA gene and ITS amplicon sequencing from PacBio reads

HiFiTaxa is a Nextflow pipeline for analyzing PacBio HiFi reads of 16S rRNA and ITS amplicons, offering multiple classifiers and benchmarking their performance on mock communities and holdouts.

Non-equilibrium cyclic conformations of DNA under electrokinetic confinement

This study introduces RECON, a technique that dynamically controls DNA conformations in nanowells, enabling access to non-equilibrium states through periodic and stochastic signals.

An Innate Neuroprotective Reflex Activates NRF2 via Phosphorylation of p62 at Ser351 to Mitigate Traumatic Brain Injury

This paper shows that artificial diving reflex via trigeminal nerve stimulation activates NRF2 through p62 phosphorylation, offering neuroprotection in traumatic brain injury without depleting antioxidant reserves.

Disentangling visual and motor contributions to continuous psychophysics

This study disentangles visual and motor contributions to tracking performance in continuous psychophysics by analyzing cross-correlogram metrics under visual impairment and hand dominance conditions.

A single day of natural daylight exposure and physical activity does not conclusively change circadian phase: A Bayesian crossover experiment

This study investigates the effects of natural daylight and physical activity on circadian phase using a Bayesian crossover experiment, finding inconclusive results.

Characterising cortical perturbation-recovery dynamics using TMSEEG: The Brain Dynamic Metric Toolbox

This study uses TMS-EEG and a new toolbox to analyze cortical recovery dynamics after perturbation, finding that extended post-stimulation analysis reveals LICI-related differences in resilience and temporal memory.

Facilitating the identification of cryo-EM hit matter in drug discovery with Astex-Faro

Astex-Faro improves cryo-EM hit identification by detecting structural deviations and enhancing weak features across diverse datasets.