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This study shows Apelin signaling regulates neuroendocrine homeostasis in zebrafish via Atoh8-dependent transcriptional control, affecting development, fertility, and aging.

The paper identifies Rab10 modulators through virtual screening and evaluates their effects on Alzheimer's disease-related cellular phenotypes.

This study investigates how partial agonists affect desensitization in KARs, showing that agonist residence time and LBD closure are more critical than subunit composition in heteromeric receptors.

This study identifies factors influencing Sleeping Beauty transposition, showing chromatin context, cargo size, and transcriptional activity affect efficiency and reintegration patterns.

This study shows that removing maternal compensation in zebrafish reveals retinal-specific roles for Pomgnt1, with retinal abnormalities appearing early and behavioral changes observed.

HLAResolver improves HLA resolution in T-cell response data by integrating MIRA responses with NetMHCpan predictions, achieving higher sensitivity and fewer candidate HLAs.

The paper investigates the mcm4Chaos3 mutation in yeast, showing it causes genome instability by impairing specific centromere-proximal origins.

The paper identifies a non-canonical helical binding motif in MAD1 that specifically interacts with Cyclin B1 to recruit CDK1 to the SAC, revealing a mechanism for B-type cyclin recognition.

The paper proposes a Bayesian model explaining how the circadian clock integrates light intensity and wavelength to estimate astronomical time despite natural variability.

The paper assesses the robustness of immune transcriptomic recovery after myocardial infarction by evaluating how missing data and assay availability affect inflammatory-response scores over time.

This paper develops a theoretical framework to analyze cardiac-autonomic regulation using dynamical systems theory and demonstrates its properties through simulations.

The paper identifies a HNRNPU-CHD2 RNA-processing axis linked to neurodevelopmental disease by showing HNRNPU depletion causes splicing changes in CHD2 that may lead to nonsense-mediated decay.

This study uses recombinant sortase to attach antigens to Gram-positive bacteria, demonstrating a non-genetic method to induce protective immunity in vivo.

This study uses cardiac transcriptomics in mice to compare immune responses during acute and chronic Trypanosoma cruzi infection, identifying shared and divergent features.

The paper identifies distinct septal GABAergic pathways regulated by PV+ and CB+ neurons, showing they differentially support spatial memory and network activity.

This paper examines socio-demographic gradients in traumatic brain injury (TBI) disability, severity, and nutrition using global and US-based data, finding persistent disparities and nutritional risks among food-insecure TBI survivors.

The paper shows PROM1 activation in liver cancer cells shifts their state along a preexisting differentiation axis, suggesting CD133's role extends beyond being a stem-like marker.

The paper shows that mutation transmission is influenced by developmental and life-history traits, altering mutation rates and identities across species.

This study quantifies how uncertainty in acoustic and thermal tissue properties affects transcranial ultrasound exposure estimates using simulations.