Xin Jin

Socio-demographic gradients in traumatic brain injury disability, severity and nutrition: a two-level analysis of the Global Burden of Disease Study 2023 and NHANES 2011-2014

This paper examines socio-demographic gradients in traumatic brain injury (TBI) disability, severity, and nutrition using global and US-based data, finding persistent disparities and nutritional risks among food-insecure TBI survivors.

Generative Access to Make-on-Demand Chemical Space Enables Ultra-Large Virtual Screening

The paper introduces REAL-SWIT, a generative framework for ultra-large virtual screening that efficiently explores chemical space by generating molecules with favorable docking scores.

Multi-kingdom microbial diversity and interaction landscapes in mosquitoes revealed by 5,163 individual meta-transcriptomes

The paper analyzes 5,163 mosquito meta-transcriptomes to characterize microbial diversity and interactions, identifying pathogens and cross-kingdom associations.

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence

This study uses single-cell multi-omics to analyze transcript isoform and immune repertoire changes in aging human immune cells, identifying age-related molecular features in T cells and B cells.

Decoding Immune Reconstitution Failure in People Living with HIV through Single-cell Genomics

This study uses single-cell multi-omics to analyze immune reconstitution failure in HIV patients, identifying genetic and epigenetic factors and developing a predictive model.

Genetic studies of gestational diabetes mellitus in 21,813 Chinese women

This study identifies four genome-wide significant SNPs associated with GDM in Chinese women and develops an early prediction model using clinical and genetic indicators.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

A High-resolution Haplotype-resolved Reference Panel Constructed from the China Kadoorie Biobank Study

The paper constructs a high-resolution haplotype-resolved reference panel from the China Kadoorie Biobank study and demonstrates its superior performance in imputing microarray data compared to existing panels.

Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

This study reports two cases of maternal malignancies detected incidentally during noninvasive prenatal tests in Asian women, showing concordant genome disruption patterns between tumor samples and NIPT results.