Author

G. Bergers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:scRNA-seq· 4 Research Focus:cell-cell communication· 3 Organism:human· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Lambrechts· 3 shared F. M. Bosisio· 3 shared S. More· 3 shared A. A. Martinez· 2 shared A. Liston· 2 shared D. Houbaert· 2 shared G. Shankar· 2 shared L. Boon· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

D. Lambrechts

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

D. Houbaert, A. P. Nikolakopoulos, O. Mece, K. Jacobs, J. Roels, G. Shankar, M. Agrawal, S. More, M. Ganne, K. Rillaerts, L. Boon, M. Swoboda, M. Nobis, L. Mourao, F. M. Bosisio, , P. Agostinis

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

bioRxiv · Jul 17, 2023Immunology

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

J. Verhoeven, K. A. Jacobs, F. Rizzollo, F. Lodi, Y. Hua, J. Pozniak, A. N. Srinvasan, D. Houbaert, G. Shankar, S. More, M. B. Schaaf, N. Dubroja Lakic, M. Ganne, J. Lamote, J. Van Weyenbergh, , P. Agostinis

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

bioRxiv · Apr 21, 2023Cancer Biology

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop

Y. Hua, G. Vella, F. Rambow, E. Allen, A. A. Martinez, M. Duhamel, S. Junius, A. Smeets, D. Nittner, D. Laoui, S. Dimmeler, T. Hehlgans, A. Liston, G. Floris, D. Lambrechts, , G. Bergers

This paper shows that antiangiogenic immunotherapies convert postcapillary venules into high-endothelial venules that support TCF1+ T cell niches through a feed-forward loop involving CD8 and NK cells.

bioRxiv · Dec 24, 2021 · PreprintCancer Biology

Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

S. Naulaerts, D. M. Borras, A. A. Martinez, J. Messiaen, Y. Van Herck, L. Gelens, T. Venken, I. Vanmeerbeek, S. More, J. Sprooten, O. Bechter, G. Bergers, A. Liston, S. De Vleeschouwer, B. J. Van den Eynde, , A. D. Garg

This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.

bioRxiv · Nov 22, 2021Immunology