R. Nevo

Membrane protein sequence features direct post-translational insertion

The paper shows that C-terminal tails of membrane proteins influence post-translational insertion of transmembrane helices, with sequence changes causing functional defects and disease.

Cancer-associated fibroblasts serve as decoys to suppress NK cell anti-cancer cytotoxicity

The paper shows cancer-associated fibroblasts suppress NK cell cytotoxicity by acting as decoys, leading to poor disease outcomes in breast cancer.

Designed active-site library reveals thousands of functional GFP variants

The paper designs a library of functional GFP variants using a machine-learning approach, recovering over 16,000 unique sequences with improved thermostability and fluorescence properties.

Acanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection

This study generates a de novo transcriptome of Acanthamoeba polyphaga and analyzes host and virus transcriptome dynamics during Mimivirus infection, revealing cell cycle arrest and host gene modulation.

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling

This study shows BRCA mutations in pancreatic cancer alter CAF subtypes, specifically increasing CLU+ CAFs, and links this to HSF1 signaling.

Cancer-associated fibroblast compositions change with breast cancer progression linking S100A4 and PDPN ratios with clinical outcome

The paper tracks changes in cancer-associated fibroblast (CAF) subpopulations during breast cancer progression, linking their ratios to clinical outcomes and BRCA mutations.

CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

This study identifies CSNAP as a key subunit of the CSN complex that modulates CRL activity through steric inhibition, affecting cell viability and DNA damage response.