Author

A. Boletta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:metabolomics· 2 Organism:mouse· 2

Frequent Co-Authors

A. Verrecchia· 2 shared B. Amati· 2 shared G. Donati· 2 shared L. Cassina· 2 shared P. Nicoli· 2 shared S. Rodighiero· 2 shared A. Bachi· 1 shared A. D'Alessandro· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. Verrecchia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression

C. Podrini, S. Clerici, L. Tronci, D. Stefanoni, T. Canu, M. Chiaravalli, D. Spies, A. S. H. Costa, A. Esposito, A. D'Alessandro, C. Frezza, A. Bachi, A. Boletta

This study shows that inhibiting asparagine synthetase (ASNS) with antisense oligonucleotides reduces kidney volume and improves renal function in PKD mice by targeting metabolic pathways.

bioRxiv · Oct 10, 2023 · PreprintBiochemistry

Oxidative stress potentiates the therapeutic action of a mitochondrial complex I inhibitor in MYC-driven B-cell lymphoma

G. Donati, P. Nicoli, A. Verrecchia, V. Vallelonga, O. Croci, S. Rodighiero, M. Audano, L. Cassina, A. Ghsein, G. Binelli, A. Boletta, N. Mitro, B. Amati

This study shows that combining a mitochondrial complex I inhibitor with oxidative stress inducers enhances the killing of MYC-driven lymphoma cells.

bioRxiv · Jun 21, 2022 · PreprintCancer Biology

Targeting mitochondrial respiration and the BCL2 family in MYC-associated B-cell lymphoma

G. Donati, M. Rava, M. Filipuzzi, P. Nicoli, L. Cassina, A. Verrecchia, M. Doni, S. Rodighiero, F. Parodi, A. Boletta, C. P. Vellano, J. R. Marszalek, G. Draetta, B. Amati

This paper identifies OxPhos as a key MYC-driven process in DLBCL and shows that targeting ETC complex I with IACS-010759 synergizes with BCL2 inhibitors to kill lymphoma cells.

bioRxiv · Nov 22, 2020Cancer Biology