Author

L. Tronci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2

Frequent Co-Authors

A. Bachi· 2 shared C. Frezza· 2 shared D. G. Ryan· 2 shared E. Nikitopoulou· 2 shared A. Avgustinova· 1 shared A. Boletta· 1 shared A. Casey· 1 shared A. Corrado· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. Bachi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression

C. Podrini, S. Clerici, L. Tronci, D. Stefanoni, T. Canu, M. Chiaravalli, D. Spies, A. S. H. Costa, A. Esposito, A. D'Alessandro, C. Frezza, A. Bachi, A. Boletta

This study shows that inhibiting asparagine synthetase (ASNS) with antisense oligonucleotides reduces kidney volume and improves renal function in PKD mice by targeting metabolic pathways.

bioRxiv · Oct 10, 2023 · PreprintBiochemistry

FADS1/2-mediated lipid metabolic reprogramming drives ferroptosis sensitivity in triple-negative breast cancer

N. Lorito, A. Subbiani, A. Smiriglia, M. Bacci, F. Bonechi, L. Tronci, A. Corrado, D. L. Longo, M. Iozzo, L. Ippolito, G. Comito, E. Giannoni, I. Meattini, A. Avgustinova, P. Chiarugi, , A. Morandi

The paper identifies FADS1/2-mediated lipid metabolic reprogramming as a driver of ferroptosis sensitivity in triple-negative breast cancer, showing that high FADS1/2 expression correlates with poor prognosis and susceptibility to ferroptosis-inducing agents.

bioRxiv · Jun 30, 2023 · PreprintCancer Biology

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

M. Sciacovelli, A. Dugourd, L. Valcarcel Jimenez, M. Yang, E. Nikitopoulou, A. S. Costa, L. Tronci, V. Caraffini, P. Rodrigues, C. Schmidt, D. G. Ryan, T. Young, V. Zecchini, S. H. Rossi, C. Massie, , C. Frezza

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response

D. G. Ryan, E. V. Knatko, A. Casey, J. L. Hukelmann, A. J. Brenes, S. Dayalan Naidu, M. Higgins, L. Tronci, E. Nikitopoulou, L. A. O'Neill, A. I. Lamond, A. Y. Abramov, D. A. Cantrell, M. P. Murphy, A. T. Dinkova-Kostova

This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.

bioRxiv · Aug 13, 2021 · PreprintImmunology