G. Donati

A comparative analysis of the antiviral response in two bat species reveals conserved and divergent innate immune pathways

This study compares antiviral responses in two bat species, finding conserved gene upregulation and divergent transcriptional patterns linked to viral tolerance and resistance.

Lifelong tissue memory relies on spatially organised dedicated progenitors located distally from the injury

The paper shows that wound repair leads to the formation of spatially organized memory progenitors that enhance future wound healing but also increase tumorigenesis risk.

Oxidative stress potentiates the therapeutic action of a mitochondrial complex I inhibitor in MYC-driven B-cell lymphoma

This study shows that combining a mitochondrial complex I inhibitor with oxidative stress inducers enhances the killing of MYC-driven lymphoma cells.

Targeting mitochondrial respiration and the BCL2 family in MYC-associated B-cell lymphoma

This paper identifies OxPhos as a key MYC-driven process in DLBCL and shows that targeting ETC complex I with IACS-010759 synergizes with BCL2 inhibitors to kill lymphoma cells.

Strong functional divergence of tropical reef fish assemblages along the global diversity gradient

The paper shows that tropical reef fish assemblages show strong trait divergence along the global diversity gradient, influenced by body size and diet, and linked to past climatic isolation of reefs.

Hair follicle stem cell progeny heal blisters while pausing skin development

The paper shows that skin blisters heal by sacrificing developmental programs, with HF stem cell progeny repairing wounds without promoting hair follicle growth.

Gene expression variability across cells and species shapes innate immunity

The paper examines how gene expression variability across cells and species influences innate immune responses, finding that rapidly diverging genes show high variability while regulatory genes are conserved.