Author

T. Hajian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

F. Li· 4 shared M. Vedadi· 4 shared A. Bolotokova· 3 shared A. Khalili Yazdi· 3 shared K. Devkota· 3 shared P. Ghiabi· 3 shared S. Perveen· 3 shared K. Wang· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

F. Li

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

K. Devkota, M. Schapira, S. Perveen, A. Khalili Yazdi, F. Li, I. Chau, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, K. J. Satchell, K. Wang, D. Li, J. Liu, D. Smil, , M. Vedadi

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

bioRxiv · Feb 19, 2021Biochemistry

A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

A. Khalili Yazdi, F. Li, K. Devkota, S. Perveen, P. Ghiabi, T. Hajian, A. Bolotokova, M. Vedadi

The paper develops a radioactivity-based high-throughput screening assay for the SARS-CoV-2 nsp10-nsp16 complex and optimizes it for HTS with a Z'-factor of 0.83.

bioRxiv · Feb 3, 2021Biochemistry

A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19

S. Perveen, A. Khalili Yazdi, K. Devkota, F. Li, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, M. Vedadi

The paper develops a fluorescence polarization assay for screening RNA-competitive inhibitors of the SARS-CoV-2 nsp10-nsp16 complex, validated with 1124 compounds.

bioRxiv · Oct 14, 2020Biochemistry

A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

X.-C. Cai, T. Zhang, E.-j. Kim, M. Jiang, K. Wang, J. Wang, S. Chen, N. Zhang, H. Wu, F. Li, C. C. dela Sena, H. Zheng, V. Vivcharuk, X. Niu, W. Zheng, , M. Luo

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

bioRxiv · Mar 27, 2019Biochemistry