Author

A. C. Purdie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:zebrafish· 4 Assay:bulk RNA-seq· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

S. H. Oehlers· 4 shared W. J. Britton· 4 shared K. de Silva· 3 shared E. Hortle· 2 shared J. A. Kasparian· 2 shared K. M. Plain· 2 shared K. Wright· 2 shared M. D. Johansen· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

S. H. Oehlers

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4 papers

Recent·Most cited

Infection-induced miR-126 suppresses tsc1- and cxcl12a-dependent permissive macrophages during mycobacterial infection

K. Wright, K. de Silva, K. M. Plain, A. C. Purdie, W. J. Britton, S. H. Oehlers

This study shows that infection-induced miR-126 suppresses tsc1 and cxcl12a to enhance macrophage function and reduce bacterial burden in zebrafish during mycobacterial infection.

bioRxiv · Oct 7, 2021 · PreprintImmunology

Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis

K. Wright, K. de Silva, K. M. Plain, A. C. Purdie, T. A. Blair, I. G. Duggin, W. J. Britton, S. H. Oehlers

This study shows that mycobacterial infection induces miR-206, which suppresses neutrophil recruitment via the CXCL12/CXCR4 axis in zebrafish.

bioRxiv · Dec 14, 2020Immunology

Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility

M. D. Johansen, E. Hortle, J. A. Kasparian, A. Romero, B. Novoa, A. Figueras, W. J. Britton, K. de Silva, A. C. Purdie, S. H. Oehlers

The paper investigates how mycobacterial infection affects host lipid metabolism in zebrafish, showing that LDLR plays a conserved role in infection susceptibility.

bioRxiv · Jul 23, 2018Immunology

Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models

M. D. Johansen, J. A. Kasparian, E. Hortle, W. J. Britton, A. C. Purdie, S. H. Oehlers

This study shows that Mycobacterium marinum infection in zebrafish leads to macrophage transdifferentiation into foam cells via the ESX1 pathogenicity locus, mirroring tuberculosis in humans.

bioRxiv · May 10, 2018Immunology