S. H. Oehlers

The study identifies a new mucosal lymphoid organ in zebrafish and other teleosts, analogous to mammalian tonsils, and describes its structure and immune function.

The paper shows that inhibiting vascular permeability in zebrafish reduces granuloma hypoxia and shifts immune cell recruitment from neutrophils to T cells, improving mycobacterial infection outcomes.

The paper identifies anti-angiogenic and vascular normalizing therapies as effective against rough M. abscessus infection in zebrafish, but finds no effect of anti-platelet drugs.

This study shows that infection-induced miR-126 suppresses tsc1 and cxcl12a to enhance macrophage function and reduce bacterial burden in zebrafish during mycobacterial infection.

The paper shows that gut microbiota from cigarette smoke-exposed mice worsens inflammation in zebrafish larvae exposed to cigarette smoke extract.

This study identifies zebrafish Hmox1a as a protective factor against mycobacterial infection by reducing iron accumulation and ferroptosis.

The paper transplants mouse high fat diet microbiota into zebrafish larvae to identify microbial factors that accelerate hyperlipidaemia via MyD88 signaling.

This study shows that OXSR1 limits potassium efflux during mycobacterial infection, thereby inhibiting inflammasome activation and reducing bacterial burden.

This study shows that anti-haemostatic drugs like warfarin, aspirin, and ticagrelor worsen UPEC sepsis in zebrafish by reducing survival and increasing bacterial load.

This study shows that mycobacterial infection induces miR-206, which suppresses neutrophil recruitment via the CXCL12/CXCR4 axis in zebrafish.

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.

The paper shows that butyrate, a short-chain fatty acid, has anti-inflammatory effects in zebrafish by reducing neutrophil and M1 macrophage recruitment to wounds, and identifies a conserved receptor for butyrate sensing in fish.

This study shows that inhibiting thrombocyte activation improves control of mycobacterial infection by reducing thrombocyte-macrophage interactions and restoring macrophage immunity.

The paper investigates how mycobacterial infection affects host lipid metabolism in zebrafish, showing that LDLR plays a conserved role in infection susceptibility.

This study shows that Mycobacterium marinum infection in zebrafish leads to macrophage transdifferentiation into foam cells via the ESX1 pathogenicity locus, mirroring tuberculosis in humans.