W. J. Britton

Spatial mapping of human lung tissue reveals granuloma diversity and histopathological superstructure in tuberculosis

This study maps spatial immune cell composition in human TB lung tissue, revealing diverse non-necrotizing aggregates surrounding necrotizing granulomas.

Treatment of infection-induced vascular pathologies is protective against persistent rough morphotype Mycobacterium abscessus infection in zebrafish

The paper identifies anti-angiogenic and vascular normalizing therapies as effective against rough M. abscessus infection in zebrafish, but finds no effect of anti-platelet drugs.

Infection-induced miR-126 suppresses tsc1- and cxcl12a-dependent permissive macrophages during mycobacterial infection

This study shows that infection-induced miR-126 suppresses tsc1 and cxcl12a to enhance macrophage function and reduce bacterial burden in zebrafish during mycobacterial infection.

Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae

The paper shows that gut microbiota from cigarette smoke-exposed mice worsens inflammation in zebrafish larvae exposed to cigarette smoke extract.

Heme oxygenase limits mycobacterial infection-induced ferroptosis

This study identifies zebrafish Hmox1a as a protective factor against mycobacterial infection by reducing iron accumulation and ferroptosis.

Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88-dependent acceleration of hyperlipidaemia by Gram positive cell wall components

The paper transplants mouse high fat diet microbiota into zebrafish larvae to identify microbial factors that accelerate hyperlipidaemia via MyD88 signaling.

OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

This study shows that OXSR1 limits potassium efflux during mycobacterial infection, thereby inhibiting inflammasome activation and reducing bacterial burden.

Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish larvae

This study shows glucose impairs haemostasis and promotes hyperlipidaemia in zebrafish larvae, with distinct effects from mammals.

Common anti-haemostatic medications increase the severity of uropathogenic Escherichia coli sepsis

This study shows that anti-haemostatic drugs like warfarin, aspirin, and ticagrelor worsen UPEC sepsis in zebrafish by reducing survival and increasing bacterial load.

Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis

This study shows that mycobacterial infection induces miR-206, which suppresses neutrophil recruitment via the CXCL12/CXCR4 axis in zebrafish.

TCR affinity controls the dynamics but not the functional specification of the Th1 response to mycobacteria

This study shows TCR affinity affects Th1 response dynamics but not functional specification during mycobacterial infection.

Advax adjuvant formulations promote protective immunity against aerosol Mycobacterium tuberculosis in the absence of deleterious inflammation and reactogenicity

This study evaluates Advax adjuvant formulations for tuberculosis vaccine efficacy, showing they provide strong protection without causing inflammation or reactogenicity.

Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection of adult zebrafish

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.

Conserved anti-inflammatory effects and sensing of butyrate in zebrafish

The paper shows that butyrate, a short-chain fatty acid, has anti-inflammatory effects in zebrafish by reducing neutrophil and M1 macrophage recruitment to wounds, and identifies a conserved receptor for butyrate sensing in fish.

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis

This paper shows that a mucosal vaccine induces lung-resident memory T cells expressing IL-17, which protect against tuberculosis, and that IL-17 is critical for this protection.

Thrombocyte inhibition restores protective immunity to mycobacterial infection

This study shows that inhibiting thrombocyte activation improves control of mycobacterial infection by reducing thrombocyte-macrophage interactions and restoring macrophage immunity.

The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets

This study shows that 4-methoxy-TEMPO reduces mycobacterial burden in zebrafish by targeting both host and bacterial redox mechanisms.

Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility

The paper investigates how mycobacterial infection affects host lipid metabolism in zebrafish, showing that LDLR plays a conserved role in infection susceptibility.

Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models

This study shows that Mycobacterium marinum infection in zebrafish leads to macrophage transdifferentiation into foam cells via the ESX1 pathogenicity locus, mirroring tuberculosis in humans.