Author

E. Hortle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:zebrafish· 7 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

W. J. Britton· 7 shared S. H. Oehlers· 6 shared M. D. Johansen· 4 shared A. C. Purdie· 2 shared J. A. Kasparian· 2 shared A. Figueras· 1 shared A. Kaur· 1 shared A. R. Fontaine· 1 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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7 shared papersImmunology

W. J. Britton

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

E. Hortle, L. V. Tran, A. R. Fontaine, N. Pinello, J. J. Wong, W. J. Britton, S. H. Oehlers

This study shows that OXSR1 limits potassium efflux during mycobacterial infection, thereby inhibiting inflammasome activation and reducing bacterial burden.

bioRxiv · Apr 21, 2021Immunology

Common anti-haemostatic medications increase the severity of uropathogenic Escherichia coli sepsis

V. L. Tran, E. Hortle, W. J. Britton, S. H. Oehlers

This study shows that anti-haemostatic drugs like warfarin, aspirin, and ticagrelor worsen UPEC sepsis in zebrafish by reducing survival and increasing bacterial load.

bioRxiv · Jan 18, 2021Immunology

Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection of adult zebrafish

E. Hortle, J. Y. Kam, E. Krogman, S. E. Warner, K. Luo, T. Cheng, P. Manuneedhi Cholan, K. Kikuchi, J. A. Triccas, W. J. Britton, M. D. Johansen, L. Kremer, S. H. Oehlers

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.

bioRxiv · Jun 6, 2020 · PreprintMicrobiology

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

E. Hortle, L. Starrs, F. Brown, J. Stephen, D. Curtis, B. McMorran, S. Foote, G. Burgio

This study shows that KCC1 activation protects mice from experimental cerebral malaria by increasing CD4+ T cells and TNF- response.

bioRxiv · Jan 31, 2019Microbiology

Thrombocyte inhibition restores protective immunity to mycobacterial infection

E. Hortle, K. E. Johnson, M. D. Johansen, T. Nguyen, J. A. Shavit, W. J. Britton, D. M. Tobin, S. H. Oehlers

This study shows that inhibiting thrombocyte activation improves control of mycobacterial infection by reducing thrombocyte-macrophage interactions and restoring macrophage immunity.

bioRxiv · Dec 1, 2018Immunology

The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets

H. D. Black, W. Xu, E. Hortle, S. I. Robertson, W. J. Britton, A. Kaur, E. J. New, P. K. Witting, B. Chami, S. Oehlers

This study shows that 4-methoxy-TEMPO reduces mycobacterial burden in zebrafish by targeting both host and bacterial redox mechanisms.

bioRxiv · Nov 11, 2018Microbiology

Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility

M. D. Johansen, E. Hortle, J. A. Kasparian, A. Romero, B. Novoa, A. Figueras, W. J. Britton, K. de Silva, A. C. Purdie, S. H. Oehlers

The paper investigates how mycobacterial infection affects host lipid metabolism in zebrafish, showing that LDLR plays a conserved role in infection susceptibility.

bioRxiv · Jul 23, 2018Immunology

Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models

M. D. Johansen, J. A. Kasparian, E. Hortle, W. J. Britton, A. C. Purdie, S. H. Oehlers

This study shows that Mycobacterium marinum infection in zebrafish leads to macrophage transdifferentiation into foam cells via the ESX1 pathogenicity locus, mirroring tuberculosis in humans.

bioRxiv · May 10, 2018Immunology