Author

M. D. Johansen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 5 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:zebrafish· 5 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

E. Hortle· 4 shared S. H. Oehlers· 4 shared W. J. Britton· 4 shared A. C. Purdie· 2 shared J. A. Kasparian· 2 shared J. Y. Kam· 2 shared L. Kremer· 2 shared T. Cheng· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

E. Hortle

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

R. Rouet, J. Y. Henry, M. D. Johansen, M. Sobti, H. Balachandran, D. B. Langley, G. Walker, H. Lenthall, J. Jackson, S. Ubiparipovic, O. Mazigi, P. Schofield, D. L. Burnett, S. H. J. Brown, M. Martinello, , D. Christ

This paper isolates broadly neutralizing SARS-CoV-2 antibodies from convalescent patients and shows they neutralize emerging variants more effectively than existing monoclonal antibodies.

bioRxiv · Oct 19, 2022Immunology

C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus

L. Paulowski, K. S. H. Beckham, M. D. Johansen, L. Berneking, N. Van, Y. Degefu, S. Staack, F. Vasquez Sotomayor, L. Asar, H. Rohde, B. B. Aldridge, M. Aepfelbacher, A. Parret, M. Wilmanns, L. Kremer, , F. P. Maurer

This study develops a C25-modified rifamycin derivative, 5j, which resists enzymatic inactivation by ArrMab and shows potent antimicrobial activity against M. abscessus in vitro and in macrophages.

bioRxiv · Jul 12, 2021Microbiology

Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection of adult zebrafish

E. Hortle, J. Y. Kam, E. Krogman, S. E. Warner, K. Luo, T. Cheng, P. Manuneedhi Cholan, K. Kikuchi, J. A. Triccas, W. J. Britton, M. D. Johansen, L. Kremer, S. H. Oehlers

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.

bioRxiv · Jun 6, 2020 · PreprintMicrobiology

High content analysis of granuloma histology and neutrophilic inflammation in adult zebrafish infected with Mycobacterium marinum

T. Cheng, J. Y. Kam, M. D. Johansen, S. Oehlers

The paper develops high-content analysis workflows to study granuloma histology and neutrophilic inflammation in adult zebrafish infected with Mycobacterium marinum, finding an inverse relationship between granuloma necrosis and neutrophil recruitment.

bioRxiv · Sep 9, 2019Immunology

Thrombocyte inhibition restores protective immunity to mycobacterial infection

E. Hortle, K. E. Johnson, M. D. Johansen, T. Nguyen, J. A. Shavit, W. J. Britton, D. M. Tobin, S. H. Oehlers

This study shows that inhibiting thrombocyte activation improves control of mycobacterial infection by reducing thrombocyte-macrophage interactions and restoring macrophage immunity.

bioRxiv · Dec 1, 2018Immunology

Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility

M. D. Johansen, E. Hortle, J. A. Kasparian, A. Romero, B. Novoa, A. Figueras, W. J. Britton, K. de Silva, A. C. Purdie, S. H. Oehlers

The paper investigates how mycobacterial infection affects host lipid metabolism in zebrafish, showing that LDLR plays a conserved role in infection susceptibility.

bioRxiv · Jul 23, 2018Immunology

Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models

M. D. Johansen, J. A. Kasparian, E. Hortle, W. J. Britton, A. C. Purdie, S. H. Oehlers

This study shows that Mycobacterium marinum infection in zebrafish leads to macrophage transdifferentiation into foam cells via the ESX1 pathogenicity locus, mirroring tuberculosis in humans.

bioRxiv · May 10, 2018Immunology