Y. Kashima

Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patients

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

Characterization of an EG.5.1 clinical isolate in vitro and in vivo

This study characterizes the in vitro and in vivo properties of the EG.5.1 SARS-CoV-2 variant, showing increased transmissibility and altered antigenicity compared to XBB.1.5.

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections

This study compares immune responses between primates and bats using single-cell RNA sequencing, revealing differences in antiviral gene induction and monocyte subsets.

Deep learning for histopathological subtyping and grading of lung adenocarcinoma

This study develops CNNs to subtype and grade lung adenocarcinoma, achieving high accuracy and outperforming most pathologists in grading prediction.

Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinoma

This paper develops an AI model for tumor cellularity evaluation in lung adenocarcinoma, validated through collaboration with pathologists to improve accuracy.

Emergence and evolution of the ERM proteins and merlin in metazoans

The paper performs a phylogenetic analysis of ERM proteins and merlin across 87 species, revealing their evolutionary origins, diversification, and functional adaptations, including tumor suppression.

The economy and environmental attitudes: Does a good economy make citizens care more about the environment?

This study examines the nonlinear relationship between economic conditions and environmental attitudes in Australia and Canada over 20 years, finding a U-shaped pattern where economic improvements initially worsen environmental attitudes but eventually increase concern.