Author

A. Chabes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Sharma· 2 shared A. Bridgeman· 1 shared A. K. Nilsson· 1 shared A. Schuh· 1 shared B. Dadonaite· 1 shared C. Cursi· 1 shared C. Koolmeister· 1 shared J. Klintman· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

S. Sharma

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2 papers

Recent·Most cited

Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

S. Sharma, C. Koolmeister, P. Tran, A. K. Nilsson, N.-G. Larsson, A. Chabes

The paper shows that mtDNA mutator mouse embryos with proofreading-deficient PolgD257A have normal total dNTP pools despite rapid cell division, contradicting previous claims of dNTP depletion.

bioRxiv · Mar 4, 2020Cell Biology

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

T. Davenne, J. Klintman, S. Sharma, R. E. Rigby, C. Cursi, A. Bridgeman, B. Dadonaite, K. De Keersmaecker, P. Hillmen, A. Chabes, A. Schuh, J. Rehwinkel

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

bioRxiv · Feb 17, 2020Cancer Biology