SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP
T. Davenne, J. Klintman, S. Sharma, R. E. Rigby, C. Cursi, A. Bridgeman, B. Dadonaite, K. De Keersmaecker, P. Hillmen, A. Chabes, A. Schuh, J. Rehwinkel
This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.
bioRxiv · Feb 17, 2020Cancer Biology