Author

A. D. Mesecar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

A. K. Chatterjee· 1 shared A. M. Mielech· 1 shared A. OBrien· 1 shared A. R. Rosales· 1 shared A. S. Anderson· 1 shared B. Boras· 1 shared B. J. Anson· 1 shared C. Allerton· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. K. Chatterjee

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16

G. Minasov, M. Rosas-Lemus, L. Shuvalova, N. L. Inniss, J. S. Brunzelle, C. M. Daczkowski, P. Hoover, A. D. Mesecar, K. J. Satchell

Science Signaling · Jun 29, 2021Peer-reviewedMicrobiology

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

B. Boras, R. M. Jones, B. J. Anson, D. Arenson, L. Aschenbrenner, M. A. Bakowski, N. Beutler, J. Binder, E. Chen, H. Eng, J. Hammond, R. Hoffman, E. P. Kadar, R. Kania, E. Kimoto, , M. E. McGrath

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

bioRxiv · Sep 12, 2020 · PreprintPharmacology & Toxicology

pH dependent inhibition from ammonium ions in the Pseudomonas mevalonii HMG-CoA Reductase crystallization environment

V. Purohit, C. N. Steussy, A. R. Rosales, C. D. Critchelow, T. Schmidt, P. Helquist, O. Wiest, A. D. Mesecar, C. V. Stauffacher

The paper investigates pH-dependent inhibition of Pseudomonas mevalonii HMG-CoA reductase in its crystallization environment, attributing the inhibition to ammonium ions and showing their effect on enzymatic activity and intermediate formation.

bioRxiv · Jun 3, 2020 · PreprintBiochemistry

Structure-Guided Mutagenesis Alters Deubiquitinating Activity 2 and Attenuates Pathogenesis of a Murine Coronavirus

X. Deng, Y. Chen, A. M. Mielech, M. Hackbart, K. R. Kesely, R. C. Mettelman, A. OBrien, M. E. Chapman, A. D. Mesecar, S. C. Baker

This study uses structure-guided mutagenesis to identify PLP2 DUB activity as an interferon antagonist in murine coronavirus pathogenesis.

Journal of Virology · May 18, 2020Peer-reviewedMicrobiology