Author

O. Wiest

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Blagg· 2 shared P. Helquist· 2 shared A. Al-Motawa· 1 shared A. Bhardwaj· 1 shared A. Cross· 1 shared A. D. Mesecar· 1 shared A. R. Rosales· 1 shared B. Ashfeld· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

B. Blagg

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

Y. Zhu, Y. Zhao, J. Wen, S. Liu, T. Huang, I. Hatial, X. Peng, H. A. Janabi, G. Huang, J. Mittlesteadt, M. Cheng, A. Bhardwaj, B. Ashfeld, K. R. Kao, D. Y. Maeda, , X. Lu

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

bioRxiv · Jun 16, 2022 · PreprintCancer Biology

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

N. H. Pipalia, S. Z. Saad, K. Subramanian, A. Cross, A. Al-Motawa, K. K. Garg, B. Blagg, L. Neckers, P. Helquist, O. Wiest, D. S. Ory, F. R. Maxfield

This study shows HSP90 inhibitors reduce cholesterol storage in NPC1 mutant fibroblasts by enhancing mutant NPC1 protein delivery to lysosomes.

bioRxiv · Apr 22, 2021Cell Biology

pH dependent inhibition from ammonium ions in the Pseudomonas mevalonii HMG-CoA Reductase crystallization environment

V. Purohit, C. N. Steussy, A. R. Rosales, C. D. Critchelow, T. Schmidt, P. Helquist, O. Wiest, A. D. Mesecar, C. V. Stauffacher

The paper investigates pH-dependent inhibition of Pseudomonas mevalonii HMG-CoA reductase in its crystallization environment, attributing the inhibition to ammonium ions and showing their effect on enzymatic activity and intermediate formation.

bioRxiv · Jun 3, 2020 · PreprintBiochemistry