Author

P. D. Charles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:Drosophila· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. Fischer· 5 shared B. M. Kessler· 4 shared B. R. Hopkins· 2 shared I. Sepil· 2 shared S. Wigby· 2 shared A. E. Handel· 1 shared A. S. Gkazi· 1 shared A. T. Pagnamenta· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersEvolutionary Biology

R. Fischer

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Author profile →

5 papers

Recent·Most cited

Deep topographic proteomics of a human brain tumour

S. Davis, C. Scott, J. Oetjen, P. D. Charles, B. M. Kessler, O. Ansorge, R. Fischer

This paper develops a workflow for spatially-resolved proteomics in human brain tumours, identifying spatial markers and immune-related protein networks in tissue slices.

bioRxiv · Mar 21, 2022Cancer Biology

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D. Charles, A. S. Gkazi, E. Adamopoulou, , G. A. Hollander

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

bioRxiv · Mar 28, 2021 · PreprintImmunology

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

E. J. Fenech, F. Lari, P. D. Charles, R. Fischer, M. Laetitia-Thezenas, K. Bagola, A. W. Paton, J. C. Paton, M. Gyrd-Hansen, B. M. Kessler, J. C. Christianson

The paper maps interactions of ER ubiquitin ligases and identifies a complex involving RNF26 that modulates innate immune signaling via the cGAS-STING pathway.

bioRxiv · Mar 18, 2020Cell Biology

BMP-signalling inhibition in Drosophila secondary cells remodels the seminal proteome, and self and rival ejaculate functions

B. R. Hopkins, I. Sepil, S. Bonham, T. Miller, P. D. Charles, R. Fischer, B. M. Kessler, C. Wilson, S. Wigby

This study shows that inhibiting BMP-signalling in Drosophila secondary cells alters seminal proteome composition and ejaculate function, revealing cross-talk between secretory cell types.

bioRxiv · Aug 21, 2019Evolutionary Biology

Ejaculate deterioration with male age, and its amelioration in Drosophila

I. Sepil, B. R. Hopkins, R. Dean, E. Bath, S. Friedman, B. Swanson, H. J. Ostridge, N. A. Buehner, M. F. Wolfner, R. Konietzny, M.-L. Thezenas, E. Sandham, P. D. Charles, R. Fischer, J. Steinhauer, , S. Wigby

The paper shows ejaculate performance declines with male age in Drosophila due to sperm and seminal protein deterioration, but this decline can be ameliorated by targeting insulin-like peptide-producing cells.

bioRxiv · Jun 28, 2019 · PreprintEvolutionary Biology