Author

A. El Daibani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

T. Che· 2 shared B. K. Kobilka· 1 shared B. Kobilka· 1 shared B. White· 1 shared C. Chen· 1 shared C. Sar· 1 shared C. Zhang· 1 shared E. O'Brien· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

T. Che

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Author profile →

2 papers

Recent·Most cited

Negative allosteric modulation of the μ-opioid receptor

E. S. O'Brien, V. A. Rangari, A. El Daibani, S. O. Eans, B. White, H. Wang, Y. Shiimura, K. Krishna Kumar, K. Appourchaux, W. Huang, C. Zhang, J. M. Mathiesen, T. Che, J. P. McLaughlin, S. Majumdar, B. K. Kobilka

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

bioRxiv · Sep 8, 2023 · PreprintBiochemistry

Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy

J. Zhao, M. Elgeti, E. O'Brien, C. Sar, A. El Daibani, J. Heng, X. Sun, T. Che, W. L. Hubbell, B. Kobilka, C. Chen

The paper uses biophysical techniques to show how ligand-induced conformational changes in the μ-opioid receptor affect its signaling efficacy.

bioRxiv · Apr 28, 2023 · PreprintBiochemistry