Author

J. Heng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

H. guo· 2 shared H. zhao· 2 shared J. li· 2 shared X. ni· 2 shared Y. he· 2 shared Y. wang· 2 shared A. El Daibani· 1 shared A. Muller· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

H. guo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

J. D. Lee, B. L. Menasche, M. Mavrikaki, M. M. Uyemura, S. M. Hong, N. Kozlova, J. Wei, M. M. Alfajaro, R. Filler, A. Muller, T. Saxena, R. R. Posey, P. Cheung, T. Muranen, J. Heng, , F. J. Slack

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

bioRxiv · Aug 31, 2023Microbiology

Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy

J. Zhao, M. Elgeti, E. O'Brien, C. Sar, A. El Daibani, J. Heng, X. Sun, T. Che, W. L. Hubbell, B. Kobilka, C. Chen

The paper uses biophysical techniques to show how ligand-induced conformational changes in the μ-opioid receptor affect its signaling efficacy.

bioRxiv · Apr 28, 2023 · PreprintBiochemistry

Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocin

H. guo, Y. wang, J. mao, H. zhao, Y. he, Y. hu, J. li, Y. li, Z. guan, C. guo, X. ni, F. zhang, J. heng

The paper presents the Cryo-EM structure of DNA polymerase θ helicase domain with and without inhibitor novobiocin, revealing a non-canonical binding pocket and insights into its mechanism.

bioRxiv · Jan 20, 2023 · PreprintBiochemistry

Cryo-EM complex structure of active GPR75 with a nanobody

Z. Lv, Y. He, Y. Xiang, J. Li, F. Meng, H. Zhao, H. Guo, D. He, Y. Wang, W. Zhuo, Y. Liu, X. Ni, J. Heng

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

bioRxiv · Aug 18, 2022 · PreprintBiophysics

Calcineurin-fusion facilitates Cryo-EM Structure Determination of a Family A GPCR

J. Xu, G. Chen, H. Wang, S. Cao, J. Heng, X. Deupi, Y. Du, B. K. Kobilka

This paper describes a method using calcineurin fusion to improve cryo-EM structure determination of Family A GPCRs by enhancing particle alignment.

bioRxiv · Mar 27, 2022Biophysics