Author

S. O. Eans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:electrophysiology· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. P. McLaughlin· 2 shared S. Majumdar· 2 shared T. Che· 2 shared A. El Daibani· 1 shared A. Faouzi· 1 shared A. M. Gutridge· 1 shared B. K. Kobilka· 1 shared B. L. Roth· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

J. P. McLaughlin

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2 papers

Recent·Most cited

Negative allosteric modulation of the μ-opioid receptor

E. S. O'Brien, V. A. Rangari, A. El Daibani, S. O. Eans, B. White, H. Wang, Y. Shiimura, K. Krishna Kumar, K. Appourchaux, W. Huang, C. Zhang, J. M. Mathiesen, T. Che, J. P. McLaughlin, S. Majumdar, B. K. Kobilka

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

bioRxiv · Sep 8, 2023 · PreprintBiochemistry

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

S. Chakraborty, J. F. Diberto, A. Faouzi, S. M. bernhard, A. M. Gutridge, S. Ramsey, Y. Zhou, D. Provasi, N. Nuthikattu, R. Jilakara, M. Nelson, W. B. Asher, S. O. Eans, L. L. Wilson, S. M. Chintala, , s. majumdar

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

bioRxiv · Apr 22, 2021Pharmacology & Toxicology