A. Esteve-Codina

The hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche

This study shows that inhibiting EGFR in hepatocytes reduces liver fibrosis by altering immune cell populations and molecular mechanisms involved in inflammation and fibrogenesis.

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

This study identifies SLFN12 as an HIV-1 restriction factor that inhibits viral replication and reactivation through codon-usage dependent post-transcriptional block in CD4+ T cells.

A TetR-like transcriptional regulator in Stenotrophomonas maltophilia involved in fatty acid metabolism is controlled by quorum sensing signals

This study identifies a TetR-like regulator in S. maltophilia that links quorum sensing signals to fatty acid metabolism and bacterial fitness during growth phase transitions.

Protamine lacking piscine spermatozoa are transcriptionally active

The paper shows that in a fish without protamine-mediated chromatin condensation, transcriptional activity in spermatozoa is necessary for motility, challenging the idea that post-meiotic sperm are transcriptionally quiescent.

Fibroblast alignment coordinates epithelial migration and maintains intestinal tissue integrity

This study shows that fibroblast alignment enhances directed migration of intestinal epithelia and maintains tissue integrity through physical and biochemical interactions.

Loss of the RNA helicase Dhx15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice

CRISPR editing of sftb-1/SF3B1 in C. elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

The paper uses CRISPR to edit sftb-1/SF3B1 in C. elegans to identify synthetic interactions with cancer mutations and test splicing inhibitors.

Time-resolved systems analysis reveals a critical role of XCR1+ 1 dendritic cells in the maintenance of effector T cells during chronic viral infection

The paper uses time-resolved transcriptomics and immunological analysis to show XCR1+ dendritic cells maintain effector T cells during chronic viral infection.