Author

T. Kaisho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. Hoshino· 2 shared K. Miyake· 2 shared Y. Fukuda-Ohta· 2 shared A. Esteve-Codina· 1 shared A. Iwasaki· 1 shared A. L. Goodman· 1 shared A. Meyerhans· 1 shared A. Yamamoto· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

K. Hoshino

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

I. Sasaki, Y. Fukuda-Ohta, C. Nakai, N. Wakaki-Nishiyama, C. Okamoto, T. Orimo, D. Okuzaki, S. Morita, S. Kaji, Y. Furuta, H. Hemmi, T. Kato, A. Yamamoto, T. Tanaka, K. Hoshino, , T. Kaisho

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

bioRxiv · Jul 6, 2023 · PreprintImmunology

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

R. Sato, K. Liu, T. Shibata, K. Hoshino, K. Yamaguchi, T. Miyazaki, R. Hiranuma, R. Fukui, Y. Motoi, Y. Fukuda-Ohta, Y. Zhang, T. Reuter, Y. Ishida, T. Kondo, T. Chiba, , K. MIYAKE

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

bioRxiv · May 11, 2023 · PreprintImmunology

Time-resolved systems analysis reveals a critical role of XCR1+ 1 dendritic cells in the maintenance of effector T cells during chronic viral infection

J. Argilaguet, M. Pedragosa, A. Esteve-Codina, G. Riera, E. Vidal, C. Peligero-Cruz, D. Andreu, T. Kaisho, G. Bocharov, B. Ludewig, S. Heath, A. Meyerhans

The paper uses time-resolved transcriptomics and immunological analysis to show XCR1+ dendritic cells maintain effector T cells during chronic viral infection.

bioRxiv · Nov 22, 2018Immunology

Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics

S. Gopinath, M. V. Kim, T. Rakib, P. W. Wong, M. van Zandt, N. A. Barry, T. Kaisho, A. L. Goodman, A. Iwasaki

This study shows aminoglycoside antibiotics provide broad antiviral protection in vivo, independent of microbiota, by inducing interferon-stimulated genes via TLR3 and XCR1+ dendritic cells.

bioRxiv · Jan 16, 2018Immunology