E. Sabido

Proteomic profiling of IDH-wildtype Glioblastoma Tissue and Serum uncovers prognostic Subtypes and Marker Candidates

This study identifies proteomic subtypes and recurrence patterns in IDH-wildtype glioblastoma using tissue and serum samples, revealing prognostic markers and proteomic plasticity in recurrent tumors.

Peroxiredoxinylation buffers the redox state of the proteome upon cellular stress

This study shows that peroxiredoxin Tsa1 in yeast peroxiredoxinylates hundreds of proteins, affecting metabolism and stress resistance, with thioredoxins removing the resulting disulfide bonds.

IKK1 kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

This study identifies IKK1's role in coordinating BRD4 and JAK/STAT signaling to resist DNA damage-based therapy in colorectal cancer.

A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution

This study reconstructs the evolutionary history of eukaryotic chromatin by combining proteomics and phylogenetic analysis, revealing pre-eukaryotic origins of chromatin functions and eukaryotic innovations.

Transcriptome innovations in primates revealed by single-molecule long-read sequencing

The paper uses long-read sequencing to identify novel transcripts and isoform changes in primate transcriptomes, highlighting immune-related regulatory divergence.

Loss of the RNA helicase Dhx15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice

Molecular characterization of triple negative breast cancer formaldehyde-fixed paraffin-embedded samples by data independent acquisition proteomics

This study uses proteomics to identify molecular subgroups and a prognostic signature in triple negative breast cancer samples, revealing differences in biological processes and potential therapeutic targets.