Human neutrophil development and functionality are enabled in a humanized mouse model
Y. Zheng, E. Sefik, J. Astle, A. G. Solis, H. H. Oz, R. Jackson, E. M. Bruscia, S. Halene, L. Shan, R. A. Flavell
This study develops a humanized mouse model, MISTRGGR, that supports the generation of functional human neutrophils in circulation and tissues, which respond to inflammatory and infectious challenges.
bioRxiv · Feb 25, 2022Immunology