Author

J. Sodroski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Finzi· 2 shared A. Herschhorn· 2 shared J. Richard· 2 shared M. Harris· 2 shared S. Ratnapriya· 2 shared A. B. Smith· 1 shared A. Chov· 1 shared A. G. Solis· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. Finzi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies

D. Parthasarathy, K. R. Pothula, K.-M. A. Dam, S. Ratnapriya, H. C. Benet, R. Parsons, X. Huang, S. Sammour, K. Janowska, M. Harris, S. Sacco, J. Sodroski, M. Bridges, W. Hubbell, P. Acharya, A. Herschhorn

This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.

bioRxiv · Sep 13, 2023Microbiology

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

C. J. Fritschi, S. Anang, Z. Gong, M. Mohammadi, J. Richard, C. Bourassa, K. T. Severino, H. Richter, D. Yang, H.-C. Chen, T.-J. Chiu, M. Seaman, N. Madani, C. Abrams, A. Finzi, , A. B. Smith

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

bioRxiv · Jan 2, 2023 · PreprintMicrobiology

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

W. Mothes, W. Li, Y. Chen, J. Prevost, I. Ullah, M. Lu, S. Y. Gong, A. Tauzin, R. Gasser, D. Vezina, S. P. Anand, G. Goyette, D. Chaterjee, S. Ding, W. D. Tolbert, , A. Finzi

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

bioRxiv · Aug 2, 2021Microbiology

Intra- and extra-cellular environments contribute to the fate of HIV-1 infection

S. Ratnapriya, M. Harris, A. Chov, V. Vrbanac, M. Deruaz, J. Sodroski, A. Herschhorn

The paper develops a system to monitor HIV-1 fate and shows that both intracellular and extracellular environments in BLT humanized mice influence HIV-1 infection outcomes.

Cell Reports · Aug 1, 2021Peer-reviewedMicrobiology

SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

P. Wang, L. Liu, M. S. Nair, M. T. Yin, Y. Luo, Q. Wang, T. Yuan, K. Mori, A. G. Solis, M. Yamashita, L. J. Purpura, J. C. Laracy, J. Yu, J. Sodroski, Y. Huang, D. D. Ho

This study finds that patients with severe SARS-CoV-2 disease have higher antibody titers against viral proteins and neutralization capabilities compared to less severe cases.

Emerging Microbes & Infections · Sep 25, 2020Peer-reviewedMicrobiology