Author

S. van Dongen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:scRNA-seq· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

K. Polanski· 2 shared L. Mamanova· 2 shared M. Patel· 2 shared R. Elmentaite· 2 shared S. A. Teichmann· 2 shared A. A. Sarshad· 1 shared A. A. Zaidi· 1 shared A. Arutyunyan· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

K. Polanski

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transcriptional signals of dedifferentiation in human cancer

G. Kildisiute, M. Kalyva, R. Elmentaite, S. van Dongen, C. Thevanesan, A. Piapi, K. Ambridge, E. Prigmore, M. Haniffa, S. A. Teichmann, K. Straathof, I. Cortes-Ciriano, S. Behjati, M. D. Young

This study examines dedifferentiation in cancer using single-cell atlases, finding that adult cancers do not revert to an embryonic state but retain foetal signals, while childhood cancers show universal foetal state features.

bioRxiv · Nov 28, 2022 · PreprintCancer Biology

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

J. Rodriguez-Ubreva, A. Arutyunyan, M. J. Bonder, L. Del Pino-Molina, S. Clark, C. de la Calle-Fabregat, L. Garcia-Alonso, L.-F. Handfield, L. Ciudad, E. Andres-Leon, F. Krueger, F. Catala-Moll, V. C. Rodriguez-Cortez, K. Polanski, L. Mamanova, , E. Ballestar

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

bioRxiv · Dec 20, 2021 · PreprintImmunology

Cells of the human intestinal tract mapped across space and time

R. Elmentaite, N. Kumasaka, H. W. King, K. Roberts, M. Dabrowska, S. Pritchard, L. Bolt, S. F. Vieira, L. Mamanova, N. Huang, I. Goh Kai'En, E. Stephenson, J. Engelbert, R. A. Botting, A. Fleming, , S. A. Teichmann

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

bioRxiv · Apr 7, 2021Cell Biology

MeshMonk: Open-source large-scale intensive 3D phenotyping

J. D. White, A. Ortega-Castrillon, H. Matthews, A. A. Zaidi, O. Ekrami, J. Snyders, Y. Fan, A. Penington, S. Van Dongen, M. D. Shriver, P. Claes

MeshMonk provides a tool for fast and accurate 3D phenotyping of images, validated with facial images and showing high precision in landmark placement.

bioRxiv · Jan 7, 2019Evolutionary Biology

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

W. Putzbach, Q. Q. Gao, M. Patel, S. van Dongen, A. Haluck-Kangas, A. A. Sarshad, E. Bartom, K.-Y. A. Kim, D. M. Scholtens, M. Hafner, J. C. Zhao, A. E. Murmann, M. E. Peter

The paper shows that many si/shRNAs targeting CD95 or CD95L induce cancer cell death via an off-target mechanism called DISE by eliminating survival genes.

bioRxiv · Sep 14, 2017Cancer Biology