Author

A. J. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Buttgereit· 1 shared A. Hernandez· 1 shared A. K. Thuhan· 1 shared C. Gineste· 1 shared C. Perry· 1 shared D. Schneidereit· 1 shared H. Westerblad· 1 shared J. A. Simpson· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Buttgereit

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

L. J. Delfinis, L. M. Ogilvie, S. Khajehzadehshoushtar, S. Gandhi, M. C. Garibotti, A. K. Thuhan, K. Matuszewska, M. Pereira, R. G. Jones, A. J. Cheng, T. J. Hawke, N. P. Greene, K. Murach, J. A. Simpson, J. Petrik, C. Perry

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

bioRxiv · Apr 8, 2024 · PreprintPhysiology

Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers

C. Gineste, S. Youhanna, S. U. Vorrink, S. Henriksson, A. Hernandez, A. J. Cheng, T. Chaillou, A. Buttgereit, D. Schneidereit, O. Friedrich, K. Hultenby, J. D. Bruton, N. Ivarsson, L. Sandblad, V. M. Lauschke, H. Westerblad

This study shows that disrupting the extracellular matrix in skeletal muscle fibers leads to mitochondrial Ca2+ uptake issues and dystrophic gene expression, which can be mitigated by Ppif inhibitors.

bioRxiv · Mar 29, 2021 · PreprintCell Biology