Author

T. J. Hawke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:differential expression· 2 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. C. Garibotti· 3 shared C. G. Perry· 2 shared I. A. Rebalka· 2 shared J. A. Simpson· 2 shared L. J. Delfinis· 2 shared M. C. Hughes· 2 shared S. Gandhi· 2 shared A. A. Abdul-Sater· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPhysiology

M. C. Garibotti

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Author profile →

4 papers

Recent·Most cited

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

L. J. Delfinis, L. M. Ogilvie, S. Khajehzadehshoushtar, S. Gandhi, M. C. Garibotti, A. K. Thuhan, K. Matuszewska, M. Pereira, R. G. Jones, A. J. Cheng, T. J. Hawke, N. P. Greene, K. Murach, J. A. Simpson, J. Petrik, C. Perry

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

bioRxiv · Apr 8, 2024 · PreprintPhysiology

Disrupted cardiac bioenergetics linked to oxidized mitochondrial creatine kinase are rescued by the mitochondrial-targeting peptide SBT-20 in the D2.mdx model of Duchenne muscular dystrophy

C. G. R. Perry, M. C. Hughes, S. V. Ramos, A. Brahmbhatt, P. C. Turnbull, N. Polidovitch, M. C. Garibotti, U. Schlattner, T. J. Hawke, J. A. Simpson, P. H. Backx

This paper investigates how mitochondrial bioenergetics are affected in D2.mdx mice and shows that SBT-20 can improve creatine-dependent bioenergetics by reducing oxidative stress.

bioRxiv · Feb 4, 2024 · PreprintPhysiology

Skeletal Muscle Mitochondrial Morphology Negatively Affected by Loss of Xin

G. Martin, D. Al-Sajee, M. Gingrich, R. Chattha, M. Akcan, C. M. Monaco, M. C. Hughes, C. G. Perry, I. A. Rebalka, M. A. Tarnopolsky, T. J. Hawke

This study shows that loss of Xin in mice leads to altered mitochondrial morphology and function in skeletal muscle, without affecting mitochondrial dynamics.

bioRxiv · Sep 14, 2023 · PreprintCell Biology

The adiponectin analogue ALY688-SR attenuates diaphragm fibrosis, atrophy and mitochondrial stress in a mouse model of Duchenne muscular dystrophy

C. A. Bellissimo, S. Gandhi, L. N. Castellani, M. Murugathasan, L. J. Delfinis, A. Thuhan, M. C. Garibotti, Y. Seo, I. A. Rebalka, G. Sweeney, T. J. Hawke, A. A. Abdul-Sater, C. G. Perry

This paper shows that ALY688-SR reduces diaphragm fibrosis and atrophy in DMD mice by lowering mitochondrial stress, but not in tibialis anterior.

bioRxiv · May 22, 2023 · PreprintPhysiology