V. M. Lauschke

Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

This study identifies virapinib, a novel inhibitor of macropinocytosis that blocks viral entry by SARS-CoV-2, Monkeypox virus, and TBEV without host cell toxicity.

Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers

This study shows that disrupting the extracellular matrix in skeletal muscle fibers leads to mitochondrial Ca2+ uptake issues and dystrophic gene expression, which can be mitigated by Ppif inhibitors.

Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions

The paper translates genotype data from 44,000 biobank participants into pharmacogenetic recommendations, finding microarrays are cost-effective and exome sequencing is inadequate for this task.