Author

M. Filizola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:electrophysiology· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

D. Provasi· 3 shared L. Salas-Estrada· 2 shared S. Ramsey· 2 shared Y. Zhou· 2 shared A. Aggarwal· 1 shared A. Faouzi· 1 shared A. J. Gonzalez-Hernandez· 1 shared A. Kapoor· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

D. Provasi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation

R. Quintana-Feliciano, J. Kottur, M. Ni, R. Ghosh, L. Salas-Estrada, O. Rechkoblit, M. Filizola, G. Fang, A. Aggarwal

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

bioRxiv · Jan 20, 2024Biophysics

Structural basis of allosteric modulation ofmetabotropic glutamate receptor activation and desensitization

A. Strauss, A. J. Gonzalez-Hernandez, J. Lee, N. Abreu, P. Selvakumar, L. Salas-Estrada, M. Kristt, D. Marx, K. Gilliland, B. Melancon, M. Filizola, J. Meyerson, J. Levitz

This study investigates how orthosteric and allosteric ligands affect mGluR activation and desensitization using electrophysiology, imaging, and cryo-EM structures.

bioRxiv · Aug 13, 2023 · PreprintBiophysics

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

S. Chakraborty, J. F. Diberto, A. Faouzi, S. M. bernhard, A. M. Gutridge, S. Ramsey, Y. Zhou, D. Provasi, N. Nuthikattu, R. Jilakara, M. Nelson, W. B. Asher, S. O. Eans, L. L. Wilson, S. M. Chintala, , s. majumdar

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

bioRxiv · Apr 22, 2021Pharmacology & Toxicology

High-resolution Structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

S. Basak, A. Kumar, S. Ramsey, E. Gibbs, A. Kapoor, M. Filizola, S. Chakrapani

This study presents high-resolution cryo-EM structures of 5-HT3AR-setron complexes, revealing distinct interaction fingerprints and a novel mechanism of competitive inhibition.

bioRxiv · Mar 30, 2020Biophysics

Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation.

X. Hu, D. Provasi, M. Filizola

This study uses molecular dynamics simulations to investigate how magnesium ions bind to and modulate the μ-opioid receptor, revealing their role in stabilizing the activated state and enhancing opioid efficacy.

Biophysical Journal · Feb 1, 2020Peer-reviewedBiophysics

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

J. Li, Y. Fukase, Y. Shang, W. Zou, J. Munoz-Felix, L. Buitrago, J. van Agthoven, Y. Zhang, R. Hara, Y. Tanaka, R. Okamoto, T. Yasui, T. Nakahata, T. Imaeda, K. Aso, , B. S. Coller

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

bioRxiv · May 24, 2019Pharmacology & Toxicology

An Efficient Strategy to Estimate Thermodynamics and Kinetics of G Protein-Coupled Receptor Activation Using Metadynamics and Maximum Caliber.

D. Meral, D. Provasi, M. Filizola

This paper develops a method combining metadynamics and maximum caliber to estimate thermodynamic and kinetic properties of GPCR activation efficiently.

bioRxiv · Jul 12, 2018Biophysics